Olmenor AM 5/40 Tablet 1 Strip

✔️ Pharmacology

Amlodipine is a long-acting dihydropyridine calcium channel blocker that inhibits calcium ion influx into vascular smooth muscle, leading to arterial vasodilation and reduced peripheral resistance.

Olmesartan Medoxomil is an angiotensin II receptor blocker (ARB) that selectively blocks the AT1 receptor, preventing vasoconstriction and aldosterone release, key mechanisms involved in hypertension. It does not inhibit ACE and thus does not affect bradykinin metabolism.

✔️

Initial dose: 5/20 mg once daily for 1–2 weeks.

Maximum dose: Up to 10/40 mg once daily, based on patient response.

Elderly (≥75 years): Due to reduced Amlodipine clearance, initiate Amlodipine separately at 2.5 mg. Fixed-dose Olmenor AM (starting at 5/20 mg) is not recommended in these patients for initial therapy.

Pediatric: Safety and efficacy not established.

Geriatric: No significant differences noted; monitor for enhanced sensitivity.

Renal impairment: Use with caution; insufficient data.

Hepatic impairment: Not recommended as initial therapy.

Dosage should be individualized based on clinical response and tolerance.

✔️ Common adverse effects include:

• Peripheral edema
• Headache
• Flushing
• Dizziness
• Sprue-like enteropathy

✔️ Drug Interactions

NSAIDs (including COX-2 inhibitors): May reduce the antihypertensive effect of Olmesartan.

Monitor: Blood pressure, renal function, and serum electrolytes during co-administration with RAS-affecting agents.

✔️ Contraindications

Do not use with Aliskiren in patients with diabetes due to the increased risk of adverse effects.

✔️ Use in Pregnancy & Lactation

Pregnancy Category D: Contraindicated in the 2nd and 3rd trimesters due to fetal toxicity. Discontinue immediately upon pregnancy detection.

Lactation: Unknown if excreted in breast milk. Use caution; consider discontinuing either the drug or breastfeeding based on clinical necessity.

✔️ Precautions & Warnings

Caution advised in patients with:

• Volume or salt depletion (risk of hypotension)
• Severe aortic stenosis (risk of severe vasodilation)
• Severe CAD (risk of worsening angina or myocardial infarction)

✔️ Storage

• Store below 30°C.
• Keep away from light and out of reach of children.