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Olmenor AM 5/40 Tablet 1 Strip
Olmenor AM | (Amlodipine + Olmesartan Medoxomil)
Therapeutic Class: Combined antihypertensive preparations
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✅ Description:
Olmenor AM is indicated for the treatment of hypertension, either as monotherapy or in combination with other antihypertensives. It is especially beneficial for patients who are likely to require multiple agents to achieve optimal blood pressure control. The decision to initiate combination therapy should be individualized, considering baseline blood pressure, therapeutic goals, and the likelihood of success with combination therapy versus monotherapy.
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✔️ Pharmacology
Amlodipine is a long-acting dihydropyridine calcium channel blocker that inhibits calcium ion influx into vascular smooth muscle, leading to arterial vasodilation and reduced peripheral resistance.
Olmesartan Medoxomil is an angiotensin II receptor blocker (ARB) that selectively blocks the AT1 receptor, preventing vasoconstriction and aldosterone release, key mechanisms involved in hypertension. It does not inhibit ACE and thus does not affect bradykinin metabolism.
✔️
Initial dose: 5/20 mg once daily for 1–2 weeks.
Maximum dose: Up to 10/40 mg once daily, based on patient response.
Elderly (≥75 years): Due to reduced Amlodipine clearance, initiate Amlodipine separately at 2.5 mg. Fixed-dose Olmenor AM (starting at 5/20 mg) is not recommended in these patients for initial therapy.
Pediatric: Safety and efficacy not established.
Geriatric: No significant differences noted; monitor for enhanced sensitivity.
Renal impairment: Use with caution; insufficient data.
Hepatic impairment: Not recommended as initial therapy.
Dosage should be individualized based on clinical response and tolerance.
✔️ Common adverse effects include:
- Peripheral edema
- Headache
- Flushing
- Dizziness
- Sprue-like enteropathy
✔️ Drug Interactions
NSAIDs (including COX-2 inhibitors): May reduce the antihypertensive effect of Olmesartan.
Monitor: Blood pressure, renal function, and serum electrolytes during co-administration with RAS-affecting agents.
✔️ Contraindications
Do not use with Aliskiren in patients with diabetes due to the increased risk of adverse effects.
✔️ Use in Pregnancy & Lactation
Pregnancy Category D: Contraindicated in the 2nd and 3rd trimesters due to fetal toxicity. Discontinue immediately upon pregnancy detection.
Lactation: Unknown if excreted in breast milk. Use caution; consider discontinuing either the drug or breastfeeding based on clinical necessity.
✔️ Precautions & Warnings
Caution advised in patients with:
- Volume or salt depletion (risk of hypotension)
- Severe aortic stenosis (risk of severe vasodilation)
- Severe CAD (risk of worsening angina or myocardial infarction)
✔️ Storage
- Store below 30°C.
- Keep away from light and out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
