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Vita D3 40000 IU Capsule 5pcs
Cholecalciferol [Vitamin D3] 40000IU is used for the treatment of Osteoporosis, Hypoparathyroidism, Rickets, Osteomalacia, Vitamin D Deficiency, Pseudohypoparathyroidism, Familial hypophosphatemia
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✅ Description:
Vitamin D3 Deficiency: Occurs in individuals with limited sunlight exposure or insufficient dietary intake. Essential for calcium and phosphate absorption, healthy bones, and teeth. Prevents rickets, osteomalacia, osteoporosis, and pre-eclampsia during pregnancy. Crucial for infant growth and immune function.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Pharmacology
- Active Form: Calcitriol binds to Vitamin D receptors (VDRs) distributed in body tissues.
- Half-life: Approximately 50 days (fat-soluble).
- Absorption & Metabolism:
- Absorbed in the small intestine.
- Transported to the liver and metabolized to 25-hydroxy Vitamin D3 (Calcidiol).
- Further hydroxylation in the kidney to 1,25-dihydroxy Vitamin D3 (Calcitriol), which increases calcium absorption.
- Stored in fat and muscle tissues.
- Eliminated via feces and urine.
✔️ Side Effects
- Rarely includes anorexia, lassitude, nausea, vomiting, diarrhea, constipation, weight loss, polyuria, sweating, headache, thirst, vertigo, and raised calcium and phosphate levels in plasma and urine.
✔️ Capsules:
- Adults:
- Treatment: 40,000 IU once weekly for 7 weeks. Maintenance: 1,400-2,000 IU/day.
- Prevention: 20,000 IU every 4 weeks. Higher doses may be required.
- Osteoporosis addition: 20,000 IU once a month.
- Children (12-18 years):
- Treatment: 20,000 IU every 2 weeks for 6 weeks.
- Prevention: 20,000 IU every 6 weeks.
- Deficient Patients:
- 0-1 year: 2,000 IU/day (+50,000 IU/week for 6 weeks).
- 1-18 years: 2,000 IU/day for 6 weeks.
✔️ Overdose Effects
- Can lead to hypervitaminosis D.
✔️ Use in Special Populations
- Safety and efficacy in children under 12 years not established.
✔️ Interactions
- Drugs that cause Vitamin D3 deficiencies by interfering with its absorption/metabolism include Magnesium-containing antacids, Digoxin, Thiazide diuretics, Cholestyramine, Cholistipol, Phenytoin, Phenobarbital, Orlistat, Mineral Oil, and Corticosteroids (e.g., Prednisolone).
✔️ Contraindications
- Hypercalcemia or known hypersensitivity to Vitamin D3 or its excipients.
- Evidence of Vitamin D3 toxicity.
✔️ Pregnancy & Lactation
- Safe use up to 4,000 IU during pregnancy. Daily intake recommendation: 400 IU. Higher doses may be required for deficient women.
- Excreted in breast milk; no overdose observed in infants from nursing mothers. Consider additional Vitamin D3 for breast-fed children.
✔️ Precautions & Warnings
- Monitor plasma calcium in high doses, renal impairment, and during pregnancy/lactation.
- Consult a healthcare practitioner for patients on Digoxin, Thiazide diuretics, or with liver/kidney disease, hyperthyroidism, lymphoma, tuberculosis, or granulomatous disease.
✔️ Storage Conditions
Store below 30ºC, protected from light and moisture. Keep out of reach of children.
Disclaimer:
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
