✔ 100% Authentic Product
👁️ Currently Viewing 423
Megabac 2 IM/IV Injection
Each vial contains Colistimethate Sodium equivalent to:
- 1 MIU (34 mg Colistin)
- 2 MIU (68 mg Colistin)
- 3 MIU (102 mg Colistin)
- 4.5 MIU (150 mg Colistin)
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Cash on Delivery - All over Bangladesh
Regular Delivery - 12-24 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
ফ্রি ডেলিভারি! - ১৪৯৯ টাকা+ অর্ডারে ঢাকা
শহরে ।
✅ Description:
Megabac is indicated for the treatment of acute and chronic infections caused by susceptible aerobic Gram-negative bacteria, particularly:
- Pseudomonas aeruginosa
- Klebsiella pneumoniae
- Escherichia coli (E. coli)
- Enterobacter aerogenes
📌 Note: Not effective against infections caused by Proteus or Neisseria.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Mechanism of Action
Colistimethate is a polycationic surface-active antibiotic that disrupts the bacterial cytoplasmic membrane, altering its permeability and leading to cell death. It binds to lipopolysaccharides in the outer membrane of gram-negative bacteria and also interacts with intracellular components like ribosomes. This bactericidal action is particularly effective against multidrug-resistant pathogens.
✔️ Dosage & Administration
🔹 Adults (Maintenance Dose):
9 MIU/day in 2–3 divided doses
Critically ill patients: Add a 9 MIU loading dose before maintenance
🔹 Renal Impairment (Adjust dose as follows):
| Creatinine Clearance (mL/min) | Daily Dose (MIU) |
|---|---|
| 30–50 | 5.5–7.5 |
| 10–30 | 4.5–5.5 |
| <10 | 3.5 |
🔹 Hemodialysis Patients:
Non-dialysis days: 2.25 MIU/day
Dialysis days: 3 MIU/day (post-dialysis)
🔹 Pediatric Patients:
≤40 kg: 75,000–150,000 IU/kg/day in 3 divided doses
40 kg (e.g., cystic fibrosis): Higher doses may be needed
🧒 Doses based on lean body weight.
✔️ Administration Guidelines
Intermittent IV Injection:
- Inject half the daily dose slowly over 3–5 minutes, every 12 hours
Continuous Infusion:
- Administer half the dose IV over 3–5 minutes
- Infuse the remaining dose diluted in:
- 0.9% NaCl
- 5% Dextrose (with NaCl or water)
- Lactated Ringer’s Solution
- Infuse over the next 22–23 hours
Alternative IV Method:
- Dilute the prescribed dose in 50–100 mL of 0.9% NaCl, and infuse over 30–60 minutes
- ⚠ Use freshly prepared solutions within 24 hours.
🔄 Reconstitution Instructions
- IM Injection: Reconstitute with 2 mL Water for Injection
- IV Bolus: Use 5 mL Water for Injection
- Infusion: Further dilute the reconstituted solution in 50–100 mL of 0.9% NaCl
✔️ Side Effects
Common: GI upset, dizziness, slurred speech, rash, tingling sensations
Serious:
Nephrotoxicity (↑BUN, ↑creatinine, ↓urine output)
Neurotoxicity (ataxia, paresthesia, apnea, respiratory arrest)
Hypersensitivity (rash, urticaria, anaphylaxis)
✔️ Drug Interactions
Avoid concurrent use with:
- Aminoglycosides, Polymyxins (neuromuscular toxicity risk)
- Muscle relaxants (e.g., succinylcholine, tubocurarine)
- Sodium cephalothin (nephrotoxicity risk)
✔️ Contraindications
Hypersensitivity to Colistimethate Sodium or formulation components
✔️ Precautions
- Use with extreme caution in patients with renal impairment
- Monitor function in neonates, infants, and children
- Adjust the dose appropriately to avoid toxicity
- Avoid prolonged use due to the risk of neurotoxicity and nephrotoxicity
✔️ Pregnancy & Lactation
Use only if needed during pregnancy
Not known whether excreted in breast milk – caution advised in lactation
✔️ Storage Guidelines
Before reconstitution: Store below 30°C, protect from light
After reconstitution: Store at 2°C–8°C, do not freeze, use within 24 hours
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
