Macazi 500 Tablet 1 strip

✔️ Generic Name:

Azithromycin

✔️ General Administration

• Take Macazi 500 exactly as prescribed by your physician.
• Swallow the tablet whole with water; do not crush, chew, or split it.
• It may be taken with or without food, although taking it 1 hour before or 2 hours after meals is generally preferred.
• Try to take each dose at the same time every day.
• Complete the full course of therapy even if symptoms improve earlier.

Adult Dosage

Respiratory tract, skin, and soft tissue infections

• 500 mg once daily for 3 days.

Chlamydial cervicitis, urethritis, or uncomplicated genital infections

• 1 g as a single oral dose.

Uncomplicated gonorrhea

• 2 g as a single oral dose.

Chancroid

• 1 g single dose.

Granuloma inguinale

• Initial dose: 1 g, followed by 500 mg daily until complete healing.

Typhoid fever vaccination protocol

• 1 g once daily for 5 days.

Community-acquired pneumonia (IV to oral therapy)

• 500 mg IV once daily for 2 days, followed by 500 mg orally once daily to complete a 7–10-day course.

Pelvic inflammatory disease

• 500 mg IV once daily for 1–2 days, followed by 250 mg orally once daily to complete a total of 7 days.

Disseminated MAC prophylaxis

• 1.2 g once weekly.

Treatment of disseminated MAC

• 500 mg once daily in combination with other antimycobacterial agents.

Pediatric Dosage

Dosage is based on body weight and the type of infection.

Examples include:

• Otitis media: 10 mg/kg on Day 1 followed by 5 mg/kg daily for 4 days, or 10 mg/kg daily for 3 days.
• Pharyngitis: 12 mg/kg once daily for 5 days.
• Sinusitis: 10 mg/kg once daily for 3 days.
• Community-acquired pneumonia: 10 mg/kg on Day 1 followed by 5 mg/kg daily for the next 4 days.
• MAC prophylaxis: 5 mg/kg daily.

Renal Impairment

Dose adjustment is generally not required in patients with renal impairment.

Missed Dose

If you forget a dose, take it as soon as you remember. If your next scheduled dose is approaching, skip the missed dose and continue your regular schedule. Do not take two doses at the same time.

✔️ Side Effects

Common

• Nausea
• Vomiting
• Abdominal pain
• Diarrhea
• Loose stools
• Dyspepsia
• Flatulence
• Abdominal cramping

Less Common

• Headache
• Dizziness
• Fatigue
• Insomnia
• Rash
• Itching
• Vaginitis
• Constipation
• Palpitations
• Oral candidiasis

Rare but Serious

• Severe allergic reactions (including angioedema)
• Stevens-Johnson syndrome
• Cholestatic jaundice
• Pseudomembranous colitis
• Liver injury
• Cardiac arrhythmias including QT prolongation and Torsades de Pointes

Consult your healthcare provider if any side effects become severe or persistent.

✔️ Macazi 500 may interact with several medicines, including:

• Digoxin
• Cyclosporine
• Phenytoin
• Hexobarbital
• Terfenadine
• Ergot derivatives (increased risk of ergot toxicity)
• Aluminum- or magnesium-containing antacids (may reduce absorption; separate administration by at least 2 hours)
• Pimozide (contraindicated due to potentially fatal cardiac arrhythmias)

✔️ Use Macazi 500 cautiously in patients with:

• Prolonged QT interval
• Low potassium or magnesium levels
• Slow heart rate
• Existing cardiac rhythm disorders
• Liver impairment
• Kidney impairment

Regular monitoring of liver function and complete blood counts may be recommended during prolonged treatment.

Seek immediate medical attention if signs of an allergic reaction develop, including facial swelling, rash, difficulty breathing, or throat swelling.

✔️ Macazi 500 should not be used in patients with:

• Known hypersensitivity to azithromycin, erythromycin, or other macrolide or ketolide antibiotics.
• Previous cholestatic jaundice or hepatic dysfunction associated with azithromycin use.
• Concomitant use with pimozide.

✔️ Pregnancy & Lactation

Pregnancy

Available clinical evidence has not demonstrated an increased risk of major birth defects, miscarriage, or adverse pregnancy outcomes with azithromycin use. Animal studies have also shown no evidence of fetal malformations at clinically relevant doses. Nevertheless, Macazi 500 should be used during pregnancy only when clearly needed and under medical supervision.

Breastfeeding

Azithromycin is excreted into human breast milk. Although reported adverse effects in breastfed infants are generally mild, nursing mothers should monitor infants for diarrhea, vomiting, or skin rash. The benefits of breastfeeding should be weighed against the mother's clinical need for treatment.