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Levoflox is a synthetic, broad-spectrum, third-generation fluoroquinolone antibiotic used to treat mild, moderate, and severe infections caused by susceptible microorganisms. It is available for oral and intravenous use.
Levofloxacin works by inhibiting bacterial topoisomerase IV and DNA gyrase, enzymes essential for DNA replication, transcription, repair, and recombination. It is active against a wide range of gram-negative and gram-positive bacteria.
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✅ Description:
Levoflox is effective for:
- Acute maxillary sinusitis – Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
- Acute bacterial exacerbation of chronic bronchitis – S. aureus, S. pneumoniae, H. influenzae, M. catarrhalis
- Community-acquired pneumonia – S. aureus, S. pneumoniae, H. influenzae, K. pneumoniae, M. catarrhalis, C. pneumoniae, L. pneumophila, M. pneumoniae
- Urinary tract infections (uncomplicated & complicated) – E. coli, K. pneumoniae, S. saprophyticus
- Acute pyelonephritis – E. coli
- Skin & soft tissue infections (uncomplicated & complicated) – S. aureus, S. pyogenes, P. mirabilis, E. faecalis
- Enteric infections – Enterobacter spp., E. coli, Campylobacter spp., Vibrio cholerae, Shigella spp., Salmonella spp.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Pregnancy & Lactation
Not recommended during pregnancy or breastfeeding due to insufficient safety data.
✔️ Dosage & Administration
Adults
Acute sinusitis: 500 mg once daily for 10–14 days, or 750 mg once daily for 5 days
Chronic bronchitis exacerbation: 500 mg once daily for 7 days, or 750 mg once daily for 3–5 days
Community-acquired pneumonia: 500 mg once daily for 7–14 days, or 750 mg once daily for 5 days
Uncomplicated UTI: 250 mg once daily for 3 days
Complicated UTI / Acute pyelonephritis: 250 mg once daily for 7–10 days
Uncomplicated skin infections: 500 mg once daily for 7–10 days
Complicated skin infections: 750 mg once daily for 7–14 days
Enteric fever: 500 mg once daily for 7–14 days
Diarrhea, cholera, shigellosis, enteritis:
Mild–moderate: single 500 mg dose
Moderate–severe: 500 mg daily for 3 days
Children
6 months to <5 years: 10 mg/kg every 12 hours
5 years: 10 mg/kg every 24 hours
Administration
Tablets: may be taken with or without food.
✔️ Side Effects
Generally well tolerated, but may cause:
- Common: nausea, vomiting, diarrhea, abdominal pain, flatulence
- Rare: phototoxicity (0.1%), tremors, depression, anxiety, confusion
- Possible risk of retinal detachment
✔️ Drug Interactions
- Avoid co-administration with solutions containing multivalent cations (e.g., magnesium) in the same IV line.
- Antacids, iron, and adsorbents reduce absorption.
- NSAIDs may increase CNS stimulation risk.
- Warfarin may increase bleeding risk.
✔️ Contraindications
Hypersensitivity to levofloxacin, other quinolones, or product components.
✔️ Storage:
Store below 30°C, protected from light and moisture. Keep out of children’s reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
