Generic Name: Fluconazole 200mg
Manufacturer: Square Pharmaceuticals Ltd.
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Indication
Flugal 200 belongs to a class of drugs known as antifungals. Fluconazole is used to treat vaginal candidiasis, mucosal candidiasis (as oropharyngeal candidiasis, oesophagitis, mouth, throat, vagina, and other parts of the body, including fingernails and toenails, by inhibiting fungus growth and candiduria), systemic candidiasis, and cryptococcal infections (including meningitis).
Pharmacology
Fluconazole is a triazole antifungal medication that works by inhibiting the ergosterol component of fungal cell membranes. It is effective against a wide range of fungal pathogens and can be taken orally. Absorption is rapid and extensive (>90%) after oral administration. Fasting and fed states have the same bioavailability. Fluconazole's bioavailability is unaffected by gastric pH. The plasma half-life is about 30 hours. Fluconazole has a low plasma protein binding rate of 11% and is widely distributed throughout the body. The majority of the Fluconazole dose is excreted unchanged in the urine, with the remainder of the dose eliminated as metabolites.
Dosage & Administration
Adults
Children
Interaction
Concurrent use of cyclosporin or phenytoin with Fluconazole raises the plasma level of cyclosporin or phenytoin. Fluconazole and warfarin use together prolongs the prothrombin time. When combined with Fluconazole, the level of Rifampicin decreases.
Contraindications
Fluconazole is contraindicated for patients hypersensitive to this drug and with advanced liver disease.
Side Effects
Nausea, abdominal discomfort, diarrhea and flatulence, occasional abnormalities of liver enzymes; rarely rash; angioedema and anaphylaxis reported.
Pregnancy and Lactation
US FDA Pregnancy category of Fluconazole is C. So, Fluconazole ought to be maintained at a strategic distance from pregnancy and lactation unless the potential benefits to the other exceed the conceivable dangers to the baby.
Precautions & Warnings
Caution should be taken in renal impairment, pregnancy, and breastfeeding and in raised liver enzymes. The use of Fluconazole in lactating mothers is not recommended
Storage Conditions
Store below 30°C. Protect from light & moisture.
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