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Fluclox DS Powder For Suspension | 100ml
Flucloxacillin, an isoxazolyl penicillin, is effective against Gram-positive bacteria including penicillinase-producing strains. It demonstrates:
- Resistance to hydrolysis by penicillinase.
- Stability in gastric acid, allowing oral administration.
- It inhibits bacterial cell wall synthesis by binding to transpeptidase enzymes, thereby blocking cross-linking of peptidoglycan. This weakens the bacterial cell wall, leading to cell lysis and death.
Its acyl side chain provides steric hindrance, preventing β-lactam ring breakdown by bacterial penicillinase.
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বাহিরে
✅ Description:
Flucloxacillin
- Fluclox DS is prescribed for the management of infections caused by Gram-positive organisms, particularly penicillinase-producing staphylococci.
- Skin & soft tissue infections: boils, abscesses, carbuncles, infected eczema, ulcers, acne, cellulitis, impetigo, infected wounds, infected burns, furunculosis, otitis media, and otitis externa.
- Respiratory tract infections: pneumonia, lung abscess, empyema, sinusitis, tonsillitis, pharyngitis, and quinsy.
- Other infections: osteomyelitis, endocarditis, enteritis, urinary tract infections, meningitis, and septicemia caused by flucloxacillin-sensitive organisms.
- Prophylaxis: indicated during major surgical procedures (e.g., cardiothoracic and orthopedic surgery) to prevent post-operative infections.
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✔️ Side Effects
Gastrointestinal: nausea, vomiting, diarrhea, indigestion, abdominal discomfort.
Allergic reactions: rash, urticaria, fever, purpura.
Serious but rare: interstitial nephritis, hepatitis, cholestatic jaundice.
✔️ Dosage & Administration
Oral administration
Adults: 250 mg four times daily (dose may be doubled in severe infections). Up to 8 g daily may be required for osteomyelitis or endocarditis.
Children (2–10 years): half the adult dose.
Children (<2 years): one-quarter of the adult dose.
Note: Take on an empty stomach, at least 1 hour before meals.
Parenteral administration
Adults/Elderly:
IM: 250 mg four times daily.
IV: 250 mg–1 g four times daily by slow injection (3–4 minutes) or infusion.
Severe infections: doses up to 8 g daily may be required.
Children:
2–10 years: half the adult dose.
<2 years: one-quarter of the adult dose.
Other routes (in conjunction with systemic therapy):
Intra-articular: 250–500 mg daily (dissolved in lignocaine 0.5%).
Intrapleural: 250 mg daily.
By nebulizer: 125–250 mg in 3 ml sterile water, four times daily.
✔️ Drug Interactions
Concurrent use with certain drugs may increase flucloxacillin blood concentrations for prolonged periods.
✔️ Contraindications:
Known hypersensitivity to penicillins or related β-lactam antibiotics.
✔️ Pregnancy & Lactation
Pregnancy: Category B (animal studies show no risk, but no adequate human studies). Use only if clearly indicated.
Lactation: Excreted in breast milk; use with caution during breastfeeding.
✔️ Precautions & Warnings
Use with caution in patients with liver impairment or allergic predisposition.
Adjust dosage in severe renal failure (creatinine clearance <10 ml/min).
✔️ Storage:
Store in a cool, dry place away from light and heat.
Keep out of the reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
