Clavusef 125mg 4pcs

Indications of Clavusef 250 Tablet

It is indicated for the treatment of infections caused by sensitive bacteria. Pharingitis / Tonsilite caused by Pyogenes Streptococcus.

Acute Bacterial Otite Caused by Streptococcus Pneumoniae, Haemophilus Influenzae, Moraxella Catarris (Beatalactamase Producing Logs) or Streptococcus Pyogenes.

Acute bacterial maxillary sinuses caused by Streptococcus pneumonia or Hemophilus influenza (non-beta-lactamase production strains)

Infections of the lower respiratory tract, including pneumonia, caused by streptococcus pneumonia, Haemophilus influenza (including beta lactamase production logs), Klebsiella spp., Staphylococcocco Aureus. (Penicillinasi and non-penicillin production strains), Streptococcus Pyogenes, E. coli.

Acute bacterial exacerbation of chronic bronchitis and secondary bacterial infections of acute bronchitis caused by pneumonia streptococci, flu hemophile (negative Beatamasi strains) or Haemophilus paraininfluzee (beta-lactamase negative strains).

Uncomplicated skin infections and skin structure caused by Staphylococcus aureus (including beta-lactamase production strains) or streptococcus pyogenes.

urinary tract infections without complications caused by E.coli or Klebsiella pneumonia.

bone and articular infections caused by Staphylococcus aureus (penicillinase and non-penicillinase strains).

Gonorrhea without complications caused by penicillin production and stumps that produce the non-penicillinase of Neisseria Gororroae.

Initial Lyme disease (migrant erythema) caused by Borrelia burgdorferi.

Septicemia caused by Staphylococcus aureus, Streptococcus pneumonia, E.coli, Haemophilus influenzae (including ampsick strains), and Klebsiella spp.

meningitis caused by streptococcus pneumonia, Haemophilus influenza (including ampsick strains), Neisseria meningitidis & staphylococcus aureus (penicillinases and non-penicillinase production of production strains) switching therapy

(injectable to oral)

Pharmacology of Clavusef 250 Tablet

Cefuroxime is a bactericidal second-generation cephalosporin antibiotic that kills a wide spectrum of Gram-positive and Gram-negative bacteria, including many beta-lactamase-producing strains. Cefuroxime works by interfering with the transpeptidation process, which stops bacteria from making cell walls.

Streptomyces clavuligerus produces clavulanic acid, a naturally derived beta-lactamase inhibitor. It has a structure comparable to beta-lactam antibiotics, and it binds to beta-lactamase enzymes and inactivates them irreversibly. Clavulanic acid protects Cefuroxime against breakdown by beta-lactamase enzymes, making it a viable therapy option for bacterial infections.

Clavusef 250 Tablet Dosage & Administration

Adolescents and adults (13 years and older)-

Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days

Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days

Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days

Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days

Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days

Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days

Uncomplicated Gonorrhoea: 1000 mg b.i.d. Single dose

Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days

MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days

Early Lyme disease: 500 mg b.i.d. for 20 days

Paediatric Patients (3 months to 12 years)-

Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days

Acute otitis media: 30 mg/kg/day b.i.d for 10 days

Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days

Impetigo: 30 mg/kg/day b.i.d for 10 days

The cefuroxime-Clavulanic Acid tablet may be taken without regard to food.

Interaction

The area under the serum concentration versus time curve increases by 50% when probenecid and Cefuroxime-Clavulanic Acid are given together. A drug that lowers stomach acidity may impair Cefuroxime bioavailability and neutralize the impact of postprandial absorption.

Contraindications

Cefuroxime-Clavulanic Acid is not recommended for people who have a known cephalosporin allergy or who have Pseudomembranous Colitis.

Clavusef 250 Tablet Side Effects

Cefuroxime-Clavulanic Acid is generally well tolerated. However, nausea, vomiting, diarrhea, abdominal discomfort, or pain are possible adverse effects. Prolonged use of Cefuroxime and Clavulanic acid together, like other broad-spectrum antibiotics, can lead to nonsusceptible microorganism overgrowth. Renal failure, anaphylaxis, angioedema, pruritis, rash, and serum sickness, such as urticaria, can occur in a small percentage of patients (0.2 percent).

Pregnancy & Lactation

Antibiotics should be avoided if at all possible throughout the first trimester. Cefuroxime-Clavulanic Acid, on the other hand, can be safely used to treat urinary and other infections later in pregnancy. Cefuroxime-Clavulanic Acid is excreted in modest amounts in breast milk. However, the possibility of the newborn being sensitized should be considered.

Precautions & Warnings

Cefuroxime should be used with caution in individuals who are taking powerful diuretics and have a history of colitis.

Storage Conditions

Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.