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Cispenam 750 IV/IM Injection
Injection, Generic Name: Imipenem 750 mg +Cilastatin 750 mg, Manufacturer: Incepta Pharmaceuticals Ltd.
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✔️ Composition:
Imipenem + Cilastatin
✔️ Uses of Cispenam 750 IV/IM Injection
✔️ How does Cispenam 750 IV/IM Injection work?
✔️ Side Effects of Cispenam 750 IV/IM Injection
Common side effects of Imipenem include nausea, vomiting, diarrhea, rash, thrombophlebitis, thrombocytosis, neutropenia, eosinophilia, and liver and renal function abnormalities.
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✔️ Indication of Cispenam 750 IV/IM Injection
Cispenam 750, consisting of Cilastatin and Imipenem, is effective against a broad range of pathogens and is utilized in the treatment of various infections caused by susceptible bacteria, including:
- Intra-abdominal infections
- Lower respiratory tract infections
- Gynecological infections
- Septicemia
- Genitourinary tract infections
- Bone and joint infections
- Skin and soft tissue infections
- Endocarditis
✔️ Pharmacology
Imipenem, the active component of Cispenam 750, functions as an antibacterial agent by inhibiting the synthesis of bacterial cell walls in both gram-positive and gram-negative bacteria. By binding to penicillin-binding proteins (PBPs), particularly PBP-2, PBP-1a, and PBP-1b in certain bacterial strains, it disrupts cell wall production, leading to cell lysis and death.
✔️ Dosage of Cispenam 750 IV/IM Injection
The dosage of Imipenem should be tailored to the type and severity of infection, considering the susceptibility of pathogens, renal function, and body weight. It is typically administered intravenously over a specified period based on the recommended dosage guidelines for adults and pediatric patients.
✔️ Administration of Cispenam 750 IV/IM Injection
✔️ Interaction
Cilastatin may interact with probenecid, prolonging its half-life. Concurrent use with ganciclovir may increase the risk of generalized seizures.
✔️ Contraindications
Cispenam 750 is contraindicated in individuals with a history of hypersensitivity to the product.
✔️ Pregnancy & Lactation
Cispenam 750 is classified as Pregnancy Category C. Its use during pregnancy should be carefully considered, weighing the potential benefits against the risks to the fetus. Imipenem has been detected in human milk, so breastfeeding should be discontinued if Cispenam 750 is deemed essential.
✔️ Precautions & Warnings
Caution is advised when using Cispenam 750 in patients with a history of hypersensitivity to other beta-lactams, epilepsy, renal or hepatic dysfunction, and during pregnancy or breastfeeding.
✔️ Storage Conditions
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