Amotid (Amoxicillin) | Therapeutic Class: Broad-Spectrum Penicillin Antibiotic
Amoxicillin is a broad-spectrum penicillin that inhibits bacterial cell wall synthesis, leading to cell lysis and death. It is stable in gastric acid and rapidly absorbed after oral administration, with peak plasma levels reached within 1–2 hours. It distributes widely throughout body tissues and fluids.
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Amotid is indicated for the treatment of infections caused by susceptible β-lactamase-negative microorganisms, including:
Generally mild and short-lived, including diarrhea, indigestion, or rash. Rarely, pseudomembranous colitis may occur.
Adults:
250 mg three times daily; may increase to 500 mg three times daily for severe infections.
Severe respiratory infections: 3 g every 12 hours
Otitis media: 1 g three times daily
Pneumonia: 500–1000 mg three times daily
Dental abscess or UTI: 3 g, repeated after 10–12 hours
Gonorrhea: Single 2–3 g dose with 1 g Probenecid
Children (≤10 years):
125 mg three times daily; increase to 250 mg for severe infections.
Otitis media: 40 mg/kg/day in 3 divided doses (max 3 g/day)
Renal impairment: Dose adjustment may be required.
Administration Tip: Reconstituted suspension may be mixed with milk, fruit juice, or water and taken immediately.
Probenecid: Increases and prolongs amoxicillin blood levels.
Oral contraceptives: May reduce effectiveness due to altered gut flora and decreased estrogen reabsorption.
Hypersensitivity to amoxicillin or any penicillin.
Pregnancy: Category B – use only if clearly needed.
Lactation: Excreted in breast milk; use with caution in nursing mothers.
Monitor for possible superinfections (bacterial or fungal) during therapy. Discontinue treatment and initiate suitable therapy if superinfection develops.
Store in a cool, dry place (below 30°C), protected from light and heat. Keep out of reach of children.
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