Afun VT 200mg (Vaginal Tablet)

Uses of Afun VT

• Treats candidal vaginitis

How does Afun VT work?

Afun VT is an antifungal medication that acts by inhibiting fungal growth. The active ingredient, clotrimazole, works by blocking the production of enzymes that are essential for the growth of fungal cells. By interfering with these enzymes, clotrimazole disrupts the synthesis of important components in the fungal cell, such as ergosterol, which is necessary for maintaining the integrity of the cell membrane.

As a result of this inhibition, the fungal cell membrane becomes weakened and its structure is compromised. This leads to abnormalities in the fungal cell and ultimately causes damage to the cell membrane. The altered membrane activity disrupts the normal functioning of the fungus, leading to its death and preventing further growth and spread of the infection.

By targeting the enzymes involved in fungal growth and the integrity of the cell membrane, Afun VT effectively treats fungal infections by inhibiting their growth and promoting their elimination.

Side Effects of Afun VT

• Irritation
• Vaginal burning sensation
• Blisters
• Skin peeling
• Swelling
• Application site irritation

Quick Suggestions:

• Afun VT is specifically designed to treat vaginal fungal infections. To ensure proper hygiene, it is important to wash your hands before and after using the medication.
• It is recommended to avoid using Afun VT during your menstrual period. Start the treatment once your period has finished achieving better effectiveness.
• Typically, you may start feeling better within 2-3 days of treatment. However, if your symptoms do not improve or worsen, it is advisable to contact your doctor for further guidance.
• During the treatment period, it is advisable to avoid sexual intercourse and the use of other vaginal products such as tampons and spermicides. Afun VT may reduce the effectiveness of condoms and diaphragms in preventing pregnancy or sexually transmitted diseases. It is important to discuss alternative forms of protection or birth control with your doctor.
• If you are pregnant, planning to become pregnant, or currently breastfeeding, inform your doctor before using Afun VT.
• If you have a history of sexually transmitted diseases, it is important to inform your doctor.

Here are some additional tips to help prevent infection:

• Keep your feet clean and dry, especially between the toes.
• Maintain short nails and opt for open-toe shoes for daily use.
• Keep the vaginal area clean and dry.
• Use a separate clean towel for the infected area.
• Take a shower with antifungal soap after intense sweating or gym sessions.
• Avoid sharing socks, shoes, and towels with others.
• Apply a sufficient amount of Afun VT to cover the affected area and a 1-inch area around it.
• Avoid contact with the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water. Ensure regular showers and thorough drying before dressing.
• Take warm baths with mild soap.
• Avoid sharing bedding, towels, or clothes.
• It is not recommended to wear tights or tight underwear.
• Refrain from scratching the infected area, as it may spread the infection to other body parts.
• Avoid harsh soaps, deodorants, and other potentially irritating products.
• Abstain from intercourse until the thrush has been treated.
• Limit or reduce alcohol and caffeine consumption.
• Decrease intake of sugar, yeast, refined carbohydrates, and moldy foods.
• Inform your doctor if the infection persists after four weeks of treatment.
• If using Afun VT topically on the nipple area, wash your breasts before breastfeeding your child.

Indication of Afun VT

Afun VT Tablet is an antifungal medicine used to treat fungal infections of the vagina. It works by stopping the growth of the infection-causing fungi. 

Pharmacology

Clotrimazole is a broad-spectrum antifungal medication that exerts its action by binding to phospholipids in the cell membrane of fungi. This binding leads to alterations in the permeability of the cell wall, resulting in the leakage of essential intracellular elements. As a consequence, the fungal cell is unable to maintain its integrity and function properly, leading to its destruction.

By targeting the cell membrane and disrupting its structure, clotrimazole effectively combats various types of fungi, including those responsible for common fungal infections such as vaginal yeast infections, athlete's foot, and ringworm. Its broad-spectrum activity makes it a versatile antifungal agent for treating a range of fungal infections in different parts of the body.

Dosage & Administration of Afun VT

For the treatment of vaginal vulvovaginal candidiasis in adults:

First infections: A 3-day treatment is usually sufficient. Clotrimazole VT 100 or 1 Clotrimazole VT 200 should be inserted deeply into the vagina on three consecutive nights. The best position for insertion is lying on one's back with slightly bent knees.

Re-infections: Typically, a 6-day treatment is adequate. This applies to recurrent infections and mixed infections with the mentioned causative organisms. One Clotrimazole VT 100 should be inserted deeply into the vagina for six consecutive nights. If necessary, 2 Clotrimazole VT 100 (one in the morning and one in the evening) or 1 Clotrimazole VT 200 can be used daily for 6-12 days. The treatment should be scheduled to avoid the menstrual period and completed before its onset. To prevent re-infection, the partner should undergo local treatment with Clotrimazole Cream simultaneously.

should be used with caution in children and adolescents below 16 years of age. Consult your doctor before using it. should be used with caution in elderly people above 60 years. Consult your doctor before taking it.

Administration:

• Follow your physician's instructions when using Afun VT TABLET.
• This medication is intended for vaginal use only and should not be swallowed.
• To insert the tablet, use the provided applicator and place it into the vagina as high as possible.
• The optimal position for insertion is lying on your back with your legs bent up.
• It is advisable to time the treatment to avoid the menstrual period.
• The appropriate dosage and duration of treatment will be determined by your doctor based on factors such as your age, body weight, and the specific condition being treated. If you have any concerns or questions about the dosage, it is recommended to consult your doctor for clarification.

Interaction

There is a potential antagonistic interaction between imidazoles, such as Afun VT, and polyene antibiotics. Polyene antibiotics, such as amphotericin B, are antifungal medications that work by binding to the fungal cell membrane, causing damage and killing the fungus.

Imidazoles, on the other hand, work by inhibiting the growth and replication of fungi by interfering with their cell membranes and metabolic processes.

When imidazoles and polyene antibiotics are used together, there is a risk of antagonism, meaning that their effectiveness against fungal infections may be reduced. The polyene antibiotics may interfere with the action of imidazoles, leading to decreased antifungal activity.

Therefore, it is important to consult with a healthcare professional if you are using both imidazoles, such as Afun VT, and polyene antibiotics to treat fungal infections. Your healthcare provider can assess the potential risks and benefits and determine the most appropriate treatment approach for your specific condition.

Contraindications

Hypersensitivity.

Pregnancy & Lactation

During pregnancy, small amounts of imidazoles (the class of medication to which Afun VT  Tablet belongs) may be absorbed into the bloodstream after topical or vaginal administration. Therefore, caution should be exercised when using Candid-V3 Tablets during pregnancy.

The excretion of Afun VT Tablet and its components in breast milk is unknown. Therefore, it is advised to use Afun VT Tablet with caution during lactation (breastfeeding). If you are breastfeeding and considering using Afun VT Tablet, it is recommended to consult with your healthcare provider for guidance and to weigh the potential benefits against any potential risks.

Precautions & Warnings

To prevent contact with the eyes, it is important to avoid getting Afun VT Tablet in the eyes when applying it topically. It should not be used in children under the age of 3.

The use of Afun VT Tablets during pregnancy and lactation is not recommended. The excretion of the medication and its components in breast milk is unknown, so it is advised to use Afun VT Tablet with caution if you are breastfeeding. It is advisable to consult with your healthcare provider for guidance and consider the potential risks and benefits before using Afun VT Tablet during pregnancy or while breastfeeding.

Storage Conditions

• Store Afun VTt in a cool and dry below 25°C away from direct sunlight.
• Keep it out of the reach of children and pets.