Tenoren Plus | 50mg+25mg | 1 Strip

Tenoren Plus is used to treat hypertension (high blood pressure).
Lowering blood pressure reduces the risk of stroke, heart attack, and other cardiovascular events.

Take this medicine only as advised by a registered doctor.

Pharmacology

Tenoren Plus contains two active ingredients: Atenolol and Chlorthalidone.

Atenolol: A cardioselective beta-blocker (β1) that:

Lowers heart rate at rest and during exercise

Reduces systolic and diastolic blood pressure

Decreases reflex orthostatic tachycardia

Chlorthalidone: A long-acting diuretic that:

Increases excretion of sodium and chloride in the distal convoluted tubule of the kidney

Helps reduce fluid retention and blood pressure

This combination provides convenient, effective blood pressure control without reducing the bioavailability of either drug.

Dosage & Administration

Initial dose: Atenolol 50 mg + Chlorthalidone 25 mg once daily.

If response is insufficient, another antihypertensive may be added gradually, starting at 50% of the usual starting dose to avoid excessive blood pressure drop.

Renal impairment: Atenolol is excreted via the kidneys, so dosage adjustment may be necessary in severe renal dysfunction.

Elderly: Limited data for patients ≥65 years; start cautiously.

Take this medicine only as advised by a registered doctor.

Drug Interactions

May enhance effects of other antihypertensives.

Concomitant use with catecholamine depletors (e.g., reserpine) may cause low blood pressure or slow heart rate.

Calcium channel blockers or Amiodarone may have additive effects.

NSAIDs (e.g., indomethacin) may reduce antihypertensive effect.

Digitalis glycosides with beta-blockers can increase risk of bradycardia.

Contraindications

Do not take Tenoren Plus if you have:

Hypersensitivity to Atenolol, Chlorthalidone, or sulfonamide drugs

Sinus bradycardia or heart block >1st degree

Cardiogenic shock or overt heart failure

Anuria (lack of urine production)

Side Effects

Atenolol:

Bradycardia, cold extremities, postural hypotension, dizziness, vertigo, fatigue, depression, wheezing, shortness of breath

Chlorthalidone:

Electrolyte imbalance, orthostatic hypotension, nausea, vomiting, cramping, constipation, rash, photosensitivity, hyperglycemia, hyperuricemia, muscle weakness

Pregnancy & Lactation

Pregnancy Category D: Use only if benefits outweigh risks.

Breastfeeding: Exercise caution; may affect infant.

Precautions & Warnings

May worsen peripheral arterial circulation.

Periodic monitoring of serum electrolytes recommended to prevent imbalances.

Overdose Effects

Symptoms: low blood pressure, electrolyte imbalance, dehydration, slow heart rate.
Management:

Symptomatic and supportive treatment

Remove unabsorbed drug (emesis or activated charcoal)

Atenolol can be removed by hemodialysis

Therapeutic Class

Combined antihypertensive preparation

Storage

Store in a cool, dry place, protected from light.

Keep out of reach of children