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Ramipril is an angiotensin-converting enzyme (ACE) inhibitor that is converted into its active form, ramiprilat, after administration. It works by blocking the conversion of angiotensin I into angiotensin II, a potent vasoconstrictor.
This action leads to:
- Reduced levels of angiotensin II
- Decreased vasoconstriction
- Lower aldosterone secretion
As a result, blood pressure decreases, and cardiovascular protection is achieved. Ramipril is also effective in heart failure management and long-term prevention of cardiovascular events. It is well tolerated and suitable for prolonged therapy.
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100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery: 24-48 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery: 48-96 Hours, Other Cities* Charge Tk.99-125
- ফ্রি ডেলিভারিঃ - ১৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ৪৯৯৯ টাকা+ অর্ডারে, ঢাকার
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- Google Play Store থেকে ডাউনলোড
- Apple Store থেকে ডাউনলোড
📲 মোবাইল অ্যাপ অর্ডারে সাশ্রয় বেশী
✅ Description:
Ramipril is prescribed in the following conditions:
- Management of hypertension, either alone or in combination with other antihypertensive agents
- Treatment of congestive heart failure, often alongside diuretics
- Management of patients showing clinical signs of heart failure within the first few days after an acute myocardial infarction
- Treatment of diabetic and non-diabetic nephropathy (both early and established stages)
- Reduction of the risk of heart attack, stroke, and cardiovascular death in high-risk individuals, including those with:
- Coronary artery disease
- History of stroke
- Peripheral vascular disease
- Diabetes mellitus with additional risk factors (e.g., hypertension, abnormal cholesterol levels, smoking, or microalbuminuria)
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✔️ Dosage & Administration
The dose should be individualized based on patient response and tolerability.
Hypertension:
- Initial dose: 1.25–2.5 mg once daily (in patients not on diuretics)
- Dose adjustment: Gradually at intervals of at least 2 weeks
- Maintenance dose: 2.5–20 mg daily (single or divided doses)
- A diuretic may be added if needed for better control
Heart Failure after Myocardial Infarction:
- Start within 2 days post-MI
- Initial dose: 2.5 mg twice daily
- If hypotension occurs: reduce to 1.25 mg twice daily
- Target dose: up to 5 mg twice daily
Prevention of Cardiovascular Events:
- Start: 2.5 mg once daily for 1 week
- Then: 5 mg daily for 3 weeks
- Maintenance: up to 10 mg once daily
Renal Impairment:
- Hypertension: Start with 1.25 mg once daily (max 5 mg/day)
- Heart failure: Start with 1.25 mg daily, may increase up to 2.5 mg twice daily based on tolerance
✔️ Side Effects
- Dizziness
- Headache
- Fatigue and weakness
Less common effects:
- Hypotension
- Dry cough
- Nausea, vomiting, diarrhea
- Skin rash or urticaria
- Reduced urine output
Rare but serious:
- Angioedema
- Allergic reactions
- Hyperkalemia
✔️ Drug Interactions
- Concomitant use with diuretics may cause significant hypotension
- Potassium-sparing diuretics may increase the risk of hyperkalemia
- May increase serum lithium levels when used together
- Alcohol may enhance blood pressure–lowering effects and impair alertness
✔️ Ramipril should not be used in:
- Patients with hypersensitivity to ramipril or other ACE inhibitors
- History of angioedema
- Concomitant use with sacubitril/valsartan (must allow washout period)
- Patients with renal artery stenosis (bilateral or single kidney)
- Hypotensive or hemodynamically unstable patients
- Use with aliskiren in diabetic or renal impairment patients
- Patients with diabetic nephropathy taking angiotensin receptor blockers
- Pregnancy
✔️ Pregnancy & Lactation
- Contraindicated during pregnancy due to risk of fetal harm
- Should be discontinued immediately if pregnancy occurs
- Not recommended during breastfeeding
✔️ Use cautiously in patients with:
- Renal impairment
- Liver disease
- Hyperkalemia
- Hypotension
✔️ Storage:
- Store below 30°C
- Protect from light and moisture
- Keep out of reach of children
- Do not use after the expiry date
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
