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Tapazol is prescribed for:
- Hyperthyroidism in Graves’ disease or toxic multinodular goiter when surgery or radioactive iodine therapy is not suitable.
- Symptom relief before thyroidectomy or radioactive iodine therapy.
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✅ Description:
Methimazole works by inhibiting thyroid hormone synthesis, making it effective for hyperthyroidism. However, it does not deactivate already circulating or stored thyroid hormones, nor does it affect externally administered thyroid hormones. It is absorbed through the gastrointestinal tract, metabolized in the liver, and excreted via urine.
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✔️ Side Effects of Tapazol 10
Common: Rash, hives, nausea, vomiting, abdominal discomfort, joint pain, muscle weakness, headache, itching, drowsiness, dizziness, taste changes, hair loss, swelling, jaundice, and enlarged lymph nodes.
Rare but Severe:
- Agranulocytosis, thrombocytopenia, aplastic anemia
- Hepatitis, hypoprothrombinemia, nephritis
- Drug fever, lupus-like reactions, periarteritis
- Insulin autoimmune syndrome (leading to hypoglycemia).
✔️ Dosage & Administration of Tapazol 10
Adults:
- Mild hyperthyroidism: 15 mg daily
- Moderate hyperthyroidism: 30–40 mg daily
- Severe hyperthyroidism: 60 mg daily
- Maintenance dose: 5–15 mg daily
- Doses are divided into three equal parts every 8 hours.
Pediatric Patients:
- Initial dose: 0.4 mg/kg per day, divided into three doses (every 8 hours).
- Maintenance dose: Approximately half of the initial dose.
- Preferred over propylthiouracil in children due to a lower risk of severe liver injury.
Administration Note:
- Take consistently concerning meals, as food may affect absorption.
✔️ Overdose Effects of Tapazol 10
- Symptoms: Nausea, vomiting, abdominal pain, fever, joint pain, rash, drowsiness, headache, swelling.
- Severe Reactions: Aplastic anemia, agranulocytosis, liver toxicity, kidney issues, CNS effects.
- Management: Supportive care based on patient condition.
✔️ Drug Interactions
- Oral Anticoagulants (e.g., Warfarin): May increase anticoagulant activity by inhibiting vitamin K. Monitor PT/INR levels.
- Beta-Blockers: Clearance may increase in hyperthyroid patients but reduce dosage when euthyroid state is achieved.
- Digitalis Glycosides & Theophylline: Dosage adjustments may be required when patients transition from hyperthyroidism to euthyroidism.
✔️ Contraindications
Allergy or hypersensitivity to Methimazole or any of its components.
✔️ Pregnancy & Lactation
Pregnancy Category D:
- Risk of congenital malformations, particularly in the first trimester.
- Alternative treatments are recommended for pregnant women, especially in early pregnancy.
Lactation:
- Methimazole is excreted in breast milk, but studies indicate no adverse effects on infants when maternal thyroid function is well-monitored.
✔️ Precautions & Warnings
Fetal Risks:
- Methimazole crosses the placenta and may cause fetal goiter, hypothyroidism, or birth defects.
- If used in pregnancy, the lowest effective dose should be administered.
Agranulocytosis (Life-Threatening):
- Seek immediate medical attention for fever or sore throat.
- Drug should be discontinued if agranulocytosis, aplastic anemia, vasculitis, hepatitis, or severe dermatitis occurs.
Liver Toxicity:
- Lower risk than propylthiouracil but can still occur.
- Discontinue treatment if liver enzyme levels exceed 3× the upper normal limit.
Hypothyroidism Risk:
- Monitor TSH and free T4 regularly to adjust dosage appropriately.
Surgical Considerations:
- Monitor prothrombin time (PT) due to potential bleeding risk before surgical procedures.
✔️ Storage Conditions
Store below 30°C, in a cool, dry place, away from light and out of children’s reach.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
