Generic Name: Atorvastatin Calcium 10mg,
Manufacturer Name: Incepta Pharmaceuticals Limited
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Tiginor 10 is a member of the statin drug class. It lowers cholesterol and lowers the risk of developing heart disease. A fatty substance called cholesterol causes your blood vessels to narrow as it accumulates, which can result in a heart attack or stroke. When taken as directed by a doctor, the medication Tiginor 10 is frequently prescribed and is thought to be safe for long-term use.
Pharmacology
HMG-CoA reductase may be specifically inhibited by atorvastatin. This substance is the protein that restricts the rate at which HMG-CoA transforms into mevalonate, a precursor to sterols that include cholesterol. By blocking HMG-CoA reductase and cholesterol synthesis in the liver and increasing the number of hepatic LDL receptors on the cell surface for improved LDL uptake and catabolism, atorvastatin lowers plasma cholesterol and lipoprotein levels.
Patients should be placed on a standard cholesterol-lowering diet before receiving Atorvastatin and should continue on this diet during treatment with Atorvastatin. The usual starting dose for all the indications is 10 mg once daily. The dose range is 10 to 80 mg once daily. Doses should be individualised according to baseline LDL-C levels, the goal of therapy, and patient response. Adjustments of dosage should be made at intervals of 4 weeks or more. Doses may be given at any time of day with or without food.
Dosage & Administration
Primary hypercholesterolemia and combined hyperlipidemia-
Familial hypercholesterolemia-
Prevention of cardiovascular events-
Interaction
When cyclosporin, fabric corrosive derivatives, erythromycin, azole antifungals, and niacin are used simultaneously with atorvastatin treatment, the risk of myopathy increases. When Atorvastatin was administered in conjunction with antihypertensives or hypoglycemic agents, no clinically significant intuitions were observed. In the event that digoxin, erythromycin, verbal contraceptives, colestipol, stomach settling agent, or warfarin contain atorvastatin, patients should be closely monitored.
Contraindications
When a patient has a severe sensitivity to any component of this medication, atorvastatin should not be used. In cases of dynamic liver disease or unexplained elevations of serum transaminases, atorvastatin is contraindicated. Additionally, it should not be used in patients who have a history of having an actual adverse reaction to HMG-CoA reductase inhibitors in the past.
Side effects:
Atorvastatin is generally well tolerated.
Pregnancy & Lactation
Pregnancy: Atorvastatin is contraindicated during pregnancy. Security in pregnant ladies has not been built up. No controlled clinical trials with atorvastatin have been conducted in pregnant ladies. Uncommon reports of innate inconsistencies taken after the intrauterine presentation to HMG-CoA reductase inhibitors have been gotten. Creature ponders have appeared harmful to generations. Maternal treatment with atorvastatin may diminish the fetal levels of mevalonate which may be a forerunner of cholesterol biosynthesis. Atorvastatin ought to not be used in ladies who are pregnant, attempting to end up pregnant, or suspect they are pregnant. Treatment with atorvastatin ought to be suspended for the term of pregnancy or until it has been decided that the lady isn't pregnant
Lactation: It isn't known whether atorvastatin or its metabolites are excreted in the human brain. In rats, plasma concentrations of atorvastatin and its dynamic metabolites are comparable to those in the drain.
Precautions & Warnings
Effects on the liver: Liver function tests should be performed both before and after the start of treatment. Atropine should be used cautiously in patients who consume a lot of alcohol or have a history of liver disease. The use of atorvastatin should be discontinued if myopathy or significantly elevated CPK levels are discovered or suspected.
Storage Conditions
Protect from light and store in a cool, dry location. Keep out of children's reach.
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