Femastin 0.1% Cream 15gm Tube

✔️ Uses of Femastin Cream

• Postmenopausal symptoms
• Before and After vaginal surgery
• After ovarian surgery

✔️ How does Femastin 0.1% Cream work?

Femastin 0.1% Cream works by maintaining the estrogen levels in the body in menopausal women that manage the vaginal wall from becoming thin and dry thereby reducing inflammation and providing relief from menopausal symptoms due to vaginal atrophy in affected individuals.

✔️ Common side effects of Femastin 0.1% Creammay include:

• Breast tenderness
• Stomach cramps
• Bloating
• Nausea or vomiting
• Headaches
• Vaginal itching

If any of these symptoms persist or worsen, contact your doctor for further advice.

✔️ Quick Suggestions:

• Femastin Cream can be applied to the external vaginal area or inserted into the vagina using the applicator provided.
• It does not expose the rest of your body to the medicine, thereby avoiding side effects that happen more often with pills.
• Do not have sex right after using Femastin Cream as some of the medicine can be absorbed into your partner's skin.
• Regular breast screening and regular check-ups whilst using Femastin Cream are advised.
• Inform your doctor that you are using Femastin Cream if you are due to have any surgery. Your doctor might advise you to stop using Femastin Cream 4-6 weeks before the surgery to reduce the risk of a blood clot. Your doctor will decide when to start Femastin Cream again.
• Inform your doctor if you experience any vaginal bleeding or spotting, abnormal vaginal discharge, or vaginal discomfort while using this medicine.

✔️ Indication of Femastin 0.1% Cream

Femastin Cream provides relief from menopausal symptoms in women affected with vaginal atrophy

✔️ Pharmacology

Estriol, the active component in Femastin Cream, is a form of Hormone Replacement Therapy (HRT). It releases slowly in the vagina, where it is absorbed into the surrounding tissues and bloodstream. Estriol helps normalize the vaginal lining, restoring the natural microflora and maintaining the pH balance. This increases the resistance of vaginal epithelial cells to infections and inflammation. Compared to other estrogens, estriol has a shorter action, making it particularly suitable for treating symptoms related to estrogen deficiency, especially urogenital symptoms.

✔️ Dosage & Administration of Femastin 0.1% Cream

Femastin Cream should be used as directed by a doctor. Each dose contains 0.5 mg estriol. For vulvovaginal symptoms associated with menopause, a dose of cream is applied daily for 3 weeks, after which twice-weekly use may suffice. Before surgery, it is used daily for 2 weeks. For Pap smear preparations, daily application for 7 days may be advised.

Administration:

1. Open the tube using the cap's sharp point.
2. Pull the plunger to the ring-mark and attach it to the tube.
3. Squeeze the tube to fill the applicator up to the mark.
4. Remove the tube and insert the applicator deep into the vagina.
5. Slowly push the plunger to apply the cream.
6. Clean the applicator with warm, soapy water after use, and avoid detergents.

Missed doses should be applied as soon as remembered unless the next dose is due. Do not double the dose.

Femastin 0.1% Cream is unsuitable for children or adolescents, as it is intended for postmenopausal women. Elderly women (65 years and older) should use this cream only after consulting with a doctor.

✔️ Before applying Femastin, inform your doctor, if you are applying any of the following medicine:

• medicine used to manage epilepsy such as barbiturates (Ex. amobarbital, phenobarbital), hydantoins (Ex. phenytoin), carbamazepine
• medicines used to manage infections (Ex. griseofulvin, rifamycin)
• medicines used to manage viral infections (Ex. nevirapine, efavirenz, ritonavir, nelfinavir)
• St John’s wort (herbal medicine used to manage depression)
• corticosteroids (used to reduce inflammation) Ex. prednisone, prednisolone
• succinylcholine (muscle relaxant)
• theophylline (used to manage asthma)
• troleandomycin (used to manage bacterial infection)
• ombitasvir, paritaprevir, ritonavir, dasabuvir (medicines used to manage Hepatitis C)

✔️ Femastin 0.1% Cream is not recommended for patients with:

• Allergies to estriol or other ingredients.
• A history of breast or endometrial cancer, or those suspected of having these conditions.
• Blood clots (thrombosis) or a history of thrombosis.
• Unexplained vaginal bleeding.
• Uncontrolled endometrial hyperplasia.
• Heart conditions, including heart attack or blockage.
• Lung conditions like pulmonary embolism.
• Liver diseases such as benign liver tumors or Hepatitis C.

✔️ Pregnancy & Lactation

Femastin 0.1% Cream is not recommended during pregnancy or for women planning to become pregnant, as it may harm the fetus. It is also not advised for breastfeeding women due to potential risks.

✔️ Before using Femastin 0.1% Cream, inform your doctor if you have:

• Fibroids or endometriosis (growth of the womb lining outside the womb).
• Epilepsy, asthma, or otosclerosis (a condition affecting the eardrum and hearing).
• Endometrial hyperplasia (excessive growth of the womb lining).

✔️ Storage Conditions:

Store below 25°C, away from light and moisture, and keep out of reach of children.