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Tablet Manufacturer/Distributor: Acme Laboratories Ltd. Generic Name: Febuxostat 40 mg Tablet
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✅ Description:
Indications of Goustat 40
Febuxostat is indicated for the chronic management of hyperuricemia in patients with gout. Febuxostat is not recommended for the treatment of asymptomatic hyperuricemia.
Pharmacology
Febuxostat could be a non-purine, particular xanthine oxidase (XO) inhibitor. It diminishes serum uric corrosive level by repressing xanthine oxidase, which is mindful for uric corrosive generation. Xanthine oxidase breaks down hypoxanthine to xanthine and in this way to uric corrosive. Febuxostat isn't anticipated to hinder other proteins included in purine and pyrimidine amalgamation and digestion system at restorative concentrations.
Administration & Dosage
Febuxostat is recommended at 40 mg or 80 mg once daily. The recommended starting dose of Febuxostat is 40 mg once daily. For patients who do not achieve a serum uric acid less than 6 mg /dL after 2 weeks with 40 mg, Febuxostat 80 mg is recommended. Febuxostat can be administered without regard to food or antacid use. No dose adjustment is necessary when administering Febuxostat to patients with mild to moderate renal or hepatic impairment.
Interaction of Goustat 40
Concomitant administration of Febuxostat with azathioprine, mercaptopurine or theophylline could increase plasma concentrations of these drugs resulting in severe toxicity.
Contraindications
Febuxostat is contraindicated in patients being treated with azathioprine, mercaptopurine, or theophylline.
Side Effects
The most common adverse events associated with the use of Febuxostat may include liver function abnormalities, nausea, arthralgia, and rash.
Pregnancy & Lactation
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Febuxostat should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in human milk. Caution should be exercised when Febuxostat is administered to a nursing woman.
Precautions & Warnings
Gout Flare: An increment in gout flares is habitually watched amid start of anti-hyperuricemic specialists, counting Febuxostat. On the off chance that a gout flare happens amid treatment, Febuxostat require not be ceased. Prophylactic treatment (i.e., non-steroidal anti-inflammatory medicate (NSAID) or colchicine upon start of treatment) may be useful for up to six months. Cardiovascular Occasions: A better rate of cardiovascular thromboembolic occasions was watched in patients treated with febuxostat than allopurinol in clinical trials. Screen for signs and indications of MI and stroke. Liver Chemical Height: Transaminase rises have been watched in febuxostat -treated patients. Screen liver work tests intermittently.
Therapeutic Class
Drugs used in Gout
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.
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