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Vonocab Trio
- Vonoprazan: A potassium-competitive acid blocker that inhibits gastric acid secretion by targeting the H+/K+ ATPase enzyme (proton pump).
- Amoxicillin: An antibacterial drug effective against H. pylori.
- Clarithromycin: A macrolide antibiotic that enhances the eradication of H. pylori when combined with acid suppression.
The combination enhances H. pylori eradication by:
- Increasing antimicrobial stability and effectiveness.
- This promotes bacterial replication in the less acidic stomach environment, making bacteria more susceptible to antibiotics.
Discount
Price: ৳ 57
MRP:
৳
60
5%
Off
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Cash on Delivery - All over Bangladesh
Regular Delivery - 12-24 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
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✔️ Each kit contains:
- Vonoprazan 20 mg tablet (as Vonoprazan Fumarate INN)
- Amoxicillin 500 mg capsules (as Amoxicillin Trihydrate BP)
- Clarithromycin 500 mg tablet (as Clarithromycin USP)
✔️ Vonoprazan + Amoxicillin + Clarithromycin
- Active chronic gastritis
- Duodenal ulcers
- Gastric ulcers
✔️ Dosage & Administration
- Standard regimen:
- Vonoprazan 20 mg, Amoxicillin 1000 mg, and Clarithromycin 500 mg.
- Administered twice daily (morning and evening, 12 hours apart) for 14 days.
- Can be taken with or without food.
- Geriatrics: Increased risk of torsades de pointes due to clarithromycin.
- Renal impairment: Avoid in severe cases.
- Hepatic impairment: Avoid in moderate to severe cases.
✔️ Use with caution when co-administered with:
- Immunosuppressants (e.g., tacrolimus, cyclosporine).
- Antiplatelets (e.g., clopidogrel).
- CNS drugs (e.g., citalopram).
- Antifungals (e.g., itraconazole, ketoconazole).
- Antiretrovirals (e.g., ritonavir, nelfinavir).
- Other medications metabolized via CYP3A4.
✔️ Side Effects
Common side effects (>2%):
- Dysgeusia (altered taste)
- Diarrhea
- Vulvovaginal candidiasis
- Headache
- Abdominal pain
- Hypertension
- Nasopharyngitis
✔️ Contraindications
- Known hypersensitivity to any component:
- Vonoprazan
- Amoxicillin (or other beta-lactams)
- Clarithromycin (or other macrolides)
✔️ Precautions & Warnings
- Hypersensitivity reactions (e.g., anaphylaxis): Discontinue immediately if symptoms occur.
- Severe skin reactions: Stop use at the first signs.
- Clostridioides difficile-associated diarrhea (CDAD): Evaluate if diarrhea occurs.
- QT prolongation (clarithromycin component): Avoid in patients with:
- QT prolongation
- Ventricular arrhythmias (torsades de pointes)
- Electrolyte imbalances (e.g., hypokalemia, hypomagnesemia)
- Hepatotoxicity: Discontinue if signs of hepatitis appear.
- Pregnancy: Not recommended unless no alternative therapy is available.
- Myasthenia gravis: Exacerbation possible due to clarithromycin.
✔️ Storage:
- Store below 30°C.
- Keep in a dry place, protected from light.
- Keep out of reach of children.
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Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
