Vonoprazan reversibly inhibits the H⁺/K⁺-ATPase in gastric parietal cells through a potassium-competitive mechanism. Unlike conventional proton pump inhibitors, it does not require activation by gastric acid. Its strong and prolonged action at the acid-secreting site of gastric parietal cells produces potent suppression of gastric acid secretion and helps protect against acid-related damage in the upper gastrointestinal tract.
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For patients receiving:
Initial three-drug regimen: Take all three medicines twice daily for 7 days:
The clarithromycin dose may be increased when clinically appropriate, but should not exceed 400 mg twice daily.
Alternative regimen after unsuccessful PPI-based eradication therapy:
Take all three medicines twice daily for 7 days.
Take the medicine only as directed by your doctor.
Vonoprazan can be taken with or without food and does not need to be taken at a specific time in relation to meals.
Store below 30°C in a cool, dry place and protect from light. Keep out of reach of children.
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