Dexlansoprazole 60mg
Healing of Erosive Esophagitis: Canalia is indicated for the healing of all grades of erosive esophagitis (EE) for up to 8 weeks.
Maintenance of Healed Erosive Esophagitis: Canalia is indicated to maintain healing of EE and relief of heartburn for up to 6 months.
Symptomatic Non-Erosive Gastroesophageal Reflux Disease: Canalia is indicated for the treatment of heartburn associated with symptomatic non-erosive Gastroesophageal Reflux Disease (GERD) for 4 weeks.
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Dexlansoprazole delayed-release capsule is a Proton Pump Inhibitor (PPI) which suppresses gastric acid secretion by specific inhibition of the (H+/K+)-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Dexlansoprazole blocks the final step of acid production. It is the R-enantiomer of lansoprazole (A racemic mixture of the R- and S-enantiomers). Dexlansoprazole is supplied as a Dual Delayed Release (DDR) formulation in a capsule for oral administration. This capsule contains a mixture of two types of enteric-coated granules with different pH-dependent dissolution profiles. The dual delayed release formulation in dexlansoprazole shows a plasma concentration-time profile with two distinct peaks; the first peak occurs 1 to 2 hours after administration, followed by a second peak within 4 to 5 hours. After oral administration, mean Cmax and AUC values of Dexlansoprazole increased approximately dose-proportionally. Dexlansoprazole is extensively metabolized in the liver and excreted in urine.
Dexlansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation.
Common side effects: Diarrhea, abdominal pain, nausea, vomiting & flatulence.
Pregnancy Category B. There are no adequate and well-controlled studies with Dexlansoprazole in pregnant women. There are no adequate and well-controlled studies with Dexlansoprazole in lactating mothers.
Gastric Malignancy, Clostridium difficile-associated diarrhea, Bone fracture, Hypomagnesemia, and concomitant use of Canalia with Methotrexate.
Store below 30°C temperature & in a dry place, protected from light. Keep all medicines out of reach of children.
Dexlansoprazole MUPS dosing recommendations-
Dexlansoprazole can be taken without regard to food. It should be swallowed whole.
Alternatively, Dexlansoprazole capsules can be administered as follows:
Granules should not be chewed.
If a capsule is missed at its usual time, it should be taken as soon as possible. But if it is too close to the time of the next dose, only the prescribed dose should be taken at the appointed time. A double dose should not be taken.
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