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Xcel contains Paracetamol (Acetaminophen), a widely used analgesic and antipyretic. Its actions include:
- Analgesic Effect: Blocks pain signals peripherally and increases pain threshold in the central nervous system.
- Antipyretic Effect: Acts on the hypothalamus to regulate body temperature, promoting heat loss through vasodilation and sweating.
Paracetamol inhibits cyclooxygenase (COX) enzymes in the CNS (including COX-1, COX-2, and the COX-3 variant), reducing prostaglandin synthesis and thus controlling pain and fever.
Unlike NSAIDs, it does not significantly inhibit COX in peripheral tissues, giving it minimal anti-inflammatory effects.
It is less effective in tissues with high peroxide levels, which explains its central activity and limited effect on platelets or immune cells.
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✅ Description:
Xcel – Paracetamol | Therapeutic Class: Non-Opioid Analgesic
Xcel is used to relieve pain and reduce fever in both children and adults. It is effective for a wide range of conditions, including:
- Fever, common cold, and influenza
- Headache, toothache, earache, and body pain
- Muscle pain (myalgia) and nerve pain (neuralgia)
- Menstrual cramps (dysmenorrhoea)
- Sprains, colic pain, back pain, post-operative pain, and postpartum pain
- Pain associated with inflammation and post-vaccination discomfort
- Rheumatic and osteoarthritic pain, including joint stiffness
⚠️ Always use Xcel under the guidance of a registered physician.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration
Adults: 1–2 tablets every 4–6 hours, up to a maximum of 4 g (8 tablets) per day.
Children (6–12 years): ½ to 1 tablet, 3–4 times daily. The maximum daily dose should not exceed 2.6 g for long-term use.
Pediatric Use: Safe in children ≥2 years for IV or oral use
Geriatric Use: No significant difference in safety or efficacy compared to younger adults
Hepatic Impairment: Avoid in severe liver disease; dose reduction may be required
Renal Impairment: Extended dosing intervals and reduced total dose may be needed for creatinine clearance <30 ml/min
✔️ Side Effects:
Usually mild: nausea, vomiting, or skin reactions
Rare: hematological effects (thrombocytopenia, leucopenia, pancytopenia, neutropenia, agranulocytosis), pancreatitis, or severe allergic reactions
✔️ Drug Interactions
Alcohol and chronic use of barbiturates or tricyclic antidepressants may reduce Paracetamol metabolism and increase liver toxicity.
Drugs that induce liver enzymes (e.g., anticonvulsants, oral steroids) may reduce effectiveness.
✔️ Contraindications:
Hypersensitivity to Paracetamol or any components of Xcel.
✔️ Pregnancy & Lactation
Paracetamol is generally considered safe during pregnancy at recommended doses.
It is excreted in breast milk in minimal amounts and is considered clinically safe. Always consult a physician.
✔️ Precautions & Warnings
- Renal or hepatic impairment: Use with caution; may require dose adjustment
- Alcoholic liver disease: Increased risk of overdose toxicity
- Avoid multiple Paracetamol-containing products simultaneously
- Overdose can lead to severe hepatotoxicity, liver failure, hypoglycemia, metabolic acidosis, or death
- Allergic reactions: Rare but may be life-threatening; discontinue immediately if symptoms occur
✔️ Storage
Store in a dry, cool place, away from heat and light
Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
