Phenobarbitone
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Phenobarbital is a long-acting barbiturate used for its anticonvulsant and sedative-hypnotic properties, affecting GABAA receptors and calcium channels to elevate seizure thresholds and reduce seizure activity.
Adults:
Children:
Interactions Avoid concurrent use with alcohol or other CNS depressants.
Known sensitivity to phenobarbital, latent porphyria.
Common: Somnolence Less common: Agitation, confusion, hyperkinesia, ataxia, CNS depression, nausea, constipation
Serious poisoning with doses over 1 gram, potential death with 2-10 grams. Requires immediate hospitalization.
Category D: Risk to the fetus; caution advised during lactation.
Risk of tolerance, dependence, caution in mentally depressed, suicidal, or drug-abuse history patients, and those with hepatic damage.
Store below 30°C, away from light and moisture. Keep out of reach of children.
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