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Imotil Plus 2mg + 125mg Tablet 1 Strip
Loperamide-Simethicone Tablets, This medication is indicated for the symptomatic treatment of acute diarrhea in adults and adolescents (12 years and older) when associated with gas-related discomfort such as bloating, cramping, or flatulence.
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✅ Description:
- Loperamide binds to opioid receptors in the gut wall, slowing peristalsis, increasing intestinal transit time, and enhancing water and electrolyte absorption. It also improves anal sphincter tone to reduce urgency.
- Simethicone acts as an anti-foaming agent, breaking down gas bubbles in the gastrointestinal tract, which helps relieve bloating and discomfort.
- Loperamide undergoes extensive first-pass metabolism, with a bioavailability of approximately 0.3% and 95% plasma protein binding. It is primarily metabolized in the liver and excreted via bile and feces, with a half-life of about 11 hours.
- Simethicone is not absorbed and works locally in the gut.
✔️ Dosage & Administration
Adults & Adolescents (12 years & older):
- Take 2 tablets initially after the first loose stool.
- Follow with 1 tablet after each subsequent loose stool (maximum 4 tablets per day for no more than 2 days).
Children (6-11 years):
- Not recommended unless advised by a doctor.
- Ages 9-11 years: Start with 1 tablet, then ½ tablet after each loose stool (maximum 3 tablets/day).
- Ages 6-8 years: Start with 1 tablet, then ½ tablet after each loose stool (maximum 2 tablets/day).
- Use with caution in children under 12 due to variable responses and swallowing difficulties.
Elderly (65+ years):
- No dosage adjustments are required.
Patients with Renal Impairment:
- No dosage modification is necessary.
Patients with Hepatic Impairment:
- Use with caution due to the potential for increased drug levels and CNS effects.
✔️ Possible Side Effects
Common side effects (≥1%):
- Altered taste (2.6%)
- Nausea (1.6%)
✔️ Administration:
- Oral use only – tablets should be taken with a full glass (250 mL) of water.
- Chewable tablets should be fully chewed before swallowing.
- Take on an empty stomach (1 hour before or 2 hours after meals).
- Drink plenty of fluids to prevent dehydration during diarrhea episodes.
✔️ Drug Interactions
- P-glycoprotein inhibitors (quinidine, ritonavir) increase loperamide levels 2-3 times.
- CYP3A4 inhibitors (itraconazole, ketoconazole) and CYP2C8 inhibitors (gemfibrozil) raise plasma concentrations of loperamide 3-5 times.
- A combination of itraconazole & gemfibrozil results in a 13-fold increase in total plasma exposure.
- Desmopressin levels may rise 3-fold due to slower gut motility.
- Drugs that accelerate GI transit may reduce effectiveness, while those that slow peristalsis may enhance effects.
- Simethicone has no known drug interactions due to lack of absorption.
✔️ Do not use if:
- You are allergic to any component of this medication.
- You have bloody stools, fever, or acute dysentery.
- You suffer from bacterial enterocolitis (e.g., Salmonella, Shigella, Campylobacter infections).
- You have ulcerative colitis or pseudomembranous colitis caused by antibiotics.
- You experience abdominal bloating or distension, which may indicate a serious condition like toxic megacolon.
- Children under 2 years old should not take this medication.
✔️ Use During Pregnancy & Breastfeeding
- Pregnancy: Use only if clinically justified, especially during the first trimester. Animal studies do not indicate harmful effects.
- Breastfeeding: Not recommended, as small amounts of loperamide may pass into breast milk.
✔️ Precautions & Warnings
- This medication treats symptoms but does not cure underlying causes. If diarrhea persists beyond 48 hours, discontinue use and consult a doctor.
- Hepatic impairment may lead to CNS toxicity—use with caution in severe liver dysfunction.
- Cardiac risks (QT prolongation, QRS widening) have been reported in cases of overdose.
✔️ Storage Instructions
- Store below 30°C, away from light and moisture.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
