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Mylostat 500mg Capsule 7pcs
Mylostat [Hydroxyurea (Hydroxycarbamide)] is indicated for:
- Melanoma
- Resistant chronic myeloid leukemia (CML)
- Recurrent, metastatic, or inoperable carcinoma of the ovary
- Squamous cell carcinoma of the head and neck (excluding the lip, used with irradiation therapy)
- β-thalassemia, essential thrombocythemia, and polycythemia vera
- Sickle cell anemia: To reduce the frequency of painful crises and the need for transfusions.
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✅ Description:
Hydroxyurea (Antimetabolites)
Mylostat 500mg Capsule is used to manage:
- Resistant Chronic Myeloid Leukemia (CML)
- Locally advanced squamous cell carcinoma of the head and neck (excluding the lip)
- Cervical cancer
Patients with a history of blood disorders or severe anemia.
Caution Required:
- Liver, lung, or kidney diseases
- Myelosuppression (low white blood cells, red blood cells, or platelets)
- Pregnancy: Not recommended due to potential harm to the fetus (Pregnancy Category D).
- Breastfeeding: Not recommended; can harm the infant.
- Children: Not established for safety and efficacy.
- Elderly (65+ years): Use with caution; close monitoring is required.
- Avoid use due to potential risks to the fetus or breastfeeding infant.
- Dose adjustments and frequent monitoring may be necessary.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Hydroxyurea works by:
- DNA Synthesis Inhibition: Inhibits ribonucleotide reductase, stopping DNA synthesis in the S phase.
- Fetal Hemoglobin Increase: Stimulates fetal hemoglobin production, reducing sickle cell-related crises.
- Synergy with Radiation Therapy: Prevents repair of DNA damaged by radiation or chemotherapy.
✔️ Side Effects of Mylostat 500
- Gastrointestinal: Loss of appetite, nausea, diarrhea, constipation, abdominal pain
- Hematologic: Blood disorders (e.g., leukopenia, anemia, thrombocytopenia)
- Dermatologic: Hair loss, sores on lips or mouth
- General: Weakness, low back pain, unusual bleeding or bruising, muscle weakness
Severe Side Effects:
- Black tarry stools or blood in stools
- Persistent low energy or fever
- Severe mouth or throat sores
Contact your healthcare provider immediately if severe or unusual symptoms occur.
✔️ Dosage & Administration of Mylostat 500
Always wear gloves when handling capsules; do not crush or open capsules.
- Solid Tumors:
- Intermittent Therapy: 80 mg/kg orally, every 3rd day.
- Continuous Therapy: 20-30 mg/kg orally, daily.
- With Radiation: 80 mg/kg every 3rd day, starting 7 days before radiotherapy and continuing indefinitely.
- Chronic Myelocytic Leukemia: 20-30 mg/kg daily.
- Polycythemia Vera: Start with 30 mg/kg for 1 week, then 15-20 mg/kg daily.
- Essential Thrombocythemia: Initial dose 15 mg/kg/day, adjusted by platelet count.
- Sickle Cell Disease: Start at 15 mg/kg/day, adjusted based on response.
- β-Thalassemia: 15-30 mg/kg/day.
✔️ Drug Interactions:
- Increased Toxicity: Antiretrovirals (e.g., pancreatitis, hepatotoxicity, neuropathy).
- Analytical Interference: This may affect laboratory results for urea, uric acid, and lactate.
✔️ Contraindications:
Hypersensitivity to hydroxyurea or formulation components.
✔️ Pregnancy & Lactation:
- Pregnancy Category D: Risk to the fetus; women must avoid pregnancy during treatment.
- Breastfeeding: Contraindicated due to the risk of severe adverse reactions in infants.
✔️ Precautions & Warnings:
- Monitor for myelosuppression (e.g., full blood counts).
- Monitor renal and hepatic function.
- Long-term use increases the risk of secondary malignancies.
✔️ Storage Conditions:
- Store at 25°C in a dry place.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
📦Pricing Information, Availability:
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