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Hydronix 500mg Capsule 4pcs
- Hydroxyurea is metabolized into nitroxide (NO), which inhibits ribonucleotide reductase by targeting its tyrosyl radical.
- This action suppresses DNA synthesis, selectively killing cells in the S phase of the cell cycle.
- Hydroxyurea also:
- Interferes with DNA repair after radiation/chemical damage.
- Increases fetal hemoglobin levels via NO-mediated activation of soluble guanylyl cyclase, reducing sickle cell crises.
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✅ Description:
Hydronix is indicated for the treatment of various conditions, including:
Cancers:
- Melanoma
- Resistant chronic myeloid leukemia (CML)
- Recurrent metastatic or inoperable ovarian carcinoma
- Primary squamous cell carcinomas of the head and neck (excluding lip) when used with radiation therapy
- Carcinoma of the cervix
Hematological Disorders:
- β-thalassemia: Reduces painful crises and blood transfusion needs.
- Essential thrombocythemia and polycythemia vera: Helps manage platelet counts and blood consistency.
- Sickle cell anemia: Decreases the frequency of painful crises and the need for transfusions.
✔️ Uses of Hydronix 500
Treatment of Breast cancer and endometrial cancer.
✔️ How does Hydronix 500 work?
Hydronix 500 gets converted to free radical nitroxide (NO), which enters the cells, inactivates the ribonucleotide reductase enzyme, and causes immediate inhibition of DNA synthesis, leading to cell death.
✔️ Side Effects of Hydronix 500
- Common: Headache, myelosuppression, fever, chills, skin reactions.
- Serious: Acute mucocutaneous toxicity, stomatitis, erythema, hyperpigmentation, and edema (in cases of overdose).
✔️ Quick Suggestions:
- Take Hydronix 500 at the same time every day, either with or without food.
- It is advisable to stay hydrated and drink plenty of fluids while taking Hydroxyurea.
- Do not skip any dose and complete the course as suggested by your doctor.
- Use an effective method of birth control to avoid pregnancy while taking this medication.
- Your doctor may get regular blood tests done to monitor your electrolyte levels, liver function, and blood cell count in your blood.
✔️ Overdose Effects of Hydronix 500
Symptoms include mucocutaneous toxicity, severe erythema, edema of palms/soles, hyperpigmentation, and stomatitis.
✔️ Dosage & Administration of Hydronix 500
- Always use impervious gloves when handling capsules. Do not open or crush capsules.
- Dosage is based on actual or ideal weight, adjusted as needed for comorbidities and concurrent therapies.
Solid Tumors:
- Intermittent Therapy: 80 mg/kg orally every third day.
- Continuous Therapy: 20-30 mg/kg orally daily.
- With Radiation Therapy: 80 mg/kg orally every third day, starting 7 days before radiation and continuing indefinitely if tolerated.
Resistant Chronic Myelocytic Leukemia:
- Continuous therapy with 20-30 mg/kg orally daily.
Polycythemia Vera:
- Initial dose: 30 mg/kg orally daily for 1 week, followed by 15-20 mg/kg daily.
Essential Thrombocythemia:
- Initial dose: 15 mg/kg/day, adjusted based on platelet counts.
Sickle Cell Disease and β-thalassemia:
- Dose: 15-30 mg/kg orally daily, adjusted as needed.
✔️ Interaction
- Toxicity Risks: Increased risk of pancreatitis, hepatotoxicity, and peripheral neuropathy when combined with antiretroviral drugs.
- Analytical Interference: This may interfere with laboratory measurements of urea, uric acid, and lactic acid.
✔️ Pregnancy & Lactation
- Category D: Contraindicated in pregnancy due to risk to the fetus.
- Women must use contraception and discontinue breastfeeding during treatment.
✔️ Precautions & Warnings
- Causes severe myelosuppression: Do not initiate therapy in patients with significantly suppressed bone marrow.
- Monitor renal and hepatic function before and during treatment.
- A full blood count is required before and throughout treatment.
- Long-term use may lead to secondary malignancies.
✔️ Storage Conditions
- Store at 25°C in a dry place. Protect from moisture.
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