Clob 10mg Tablet

✔️ Uses of Clob 10mg Tablet

• Epilepsy
• Anxiety Disorder

✔️ How does Clob 10mg Tablet work?

Clob 10mg Tablet works by calming the brain. It binds itself to the various binding sites present in the receptor (GABA receptor) thereby causing membrane stabilization and helping to treat anxiety and fits.

✔️ Side Effects of Clob 10mg Tablet

• Restlessness
• Irritability
• Drowsiness
• Constipation
• Aggressive behaviour
• Tiredness
• Breathing problems

✔️ Quick Suggestions:

• Consistent sleep patterns contribute to overall health and well-being.
• Adequate and regular sleep is crucial, especially for individuals prone to fits.
• This type of diet is suggested to help reduce fitness.
• Engage in regular exercise.
• Maintain a healthy body weight.
• Exercise and a healthy weight contribute to overall well-being.
• Alcohol may increase drowsiness, which could potentially be exacerbated by the use of Clob 10mg Tablet.
• Do not take Clob 10mg Tablet for an extended period as it may lead to mental or physical dependence.
• Prolonged use of certain medications, especially benzodiazepines like Clob 10mg Tablet, may result in dependence.

✔️ Indications:

Anxiety Disorders:

• Symptoms include anxiety, tension, restlessness, excitement, irritability, sleep disturbances, and psychosomatic disorders.
• Should be used in individuals with depression or anxiety associated with depression, in combination with sufficient concurrent therapy.

Psychovegetative and Psychosomatic Disorders:

• Manifestations in cardiovascular or gastrointestinal areas.
• Also indicated emotional instability.

Epilepsy:

• Used as an additional treatment in individuals with epilepsy not sufficiently stabilized with anticonvulsant monotherapy.

✔️ Pharmacology

Binds to GABA receptors, increasing the time the chloride ionophore is open, leading to the enhanced inhibitory action of GABA in the CNS. Membrane hyperpolarization and stability.

✔️ Dosage & Administration of Clob 10mg Tablet

Treatment of Anxiety States:

• Adults and adolescents over 15 years: The initial dose is usually 20 mg daily, not to exceed a total daily dose of 30 mg.
• Elderly: A maintenance dose of 10 to 15 mg daily may be sufficient.
• Children (3 to 15 years): A daily dose of 5 to 10 mg is frequently sufficient.

Treatment of Epilepsy:

• Adults and adolescents over 15 years: Start at small doses (5 to 15 mg daily) and gradually increase to a maximum daily dose of about 80 mg.
• Children: Start at 5 mg daily, a maintenance dose of 0.3 to 1.0 mg/kg body weight daily is usually sufficient.

Duration and Discontinuation:

• Treatment duration should be as short as possible.
• Reassess the patient after a maximum of 4 weeks.
• The overall duration of treatment (including the tapering-off process) must not exceed 8 to 12 weeks.

Administration of Clob Tablet:

• Tablets can be administered whole or crushed and mixed in applesauce.
• 10 mg tablets can be divided into halves of 5 mg.
• Can be given with or without food.

✔️ Interaction

• Alcohol increases serum concentration.
• Hypnotics or antidepressants may increase side effects.
• Phenobarbital increases clobazam plasma concentrations.
• Enzyme inhibitor drugs may interfere with metabolism.

✔️ Contraindications

Respiratory depression, acute pulmonary insufficiency, sleep apnea syndrome, myasthenia gravis, any alcohol dependence.

✔️ Pregnancy & Lactation

Safety is not established; avoid it unless compelling reasons exist.

✔️ Precautions & Warnings

Allergy:

• Caution: Do not take Clobazam if you are known to be allergic to it.

Age Restriction:

• Recommendation: Clobazam is not recommended for children below 6 years of age.

Pregnancy and Breastfeeding:

• Advice: Do not take Clobazam if you are pregnant or breastfeeding, as it may cause adverse effects on the baby.

Elderly Patients:

• Caution: Use Clobazam with caution in elderly patients above 65 years.
• Reason: Increased risk of adverse reactions such as dizziness, muscle weakness, and drowsiness.

Medical Conditions:

• Inform Your Doctor If You Have:
  • Depression
  • Spinal or cerebellar ataxia (problems in controlling movements)
  • Hallucinations
  • Delusions (misbelief)
  • Liver or kidney problems

Specific Conditions to Avoid Clobazam:

• Avoid if You Have:
  • Myasthenia gravis (muscle weakness)
  • Sleep apnea (breathing stops and starts repeatedly)
  • Breathing or liver problems

Interaction with Opioids:

• Warning: Do not take Clobazam with opioids.
• Reason: May cause breathing problems, drowsiness, coma, and even death.

✔️ Storage Conditions

Store in a cool and dry place, protected from light.