Remus 0.03% Ointment 10gm

Uses of Remus 0.03% Ointment

Atopic dermatitis

How does Remus 0.03% Ointment work?

• Tacrolimus ointment works by blocking T-lymphocyte activation, which reduces inflammation in the skin. It inhibits the activity of calcineurin, thereby reducing the entire inflammatory cascade.

Side Effects of Remus 0.03% Ointment

The most common side effects of Remus 0.03% 10gm are application site reactions such as burning, irritation, itching, and redness.

Quick Suggestions:

• Remus 0.03% Ointment is meant for external use only. Use this medicine as directed by your doctor.
• Use Remus 0.03% Ointment at around the same time every day for ease of remembrance.
• Do not discontinue the use of this medicine without consulting your doctor.
• Do not cover the application area with bandages or other coverings.
• Avoid exposure to sunlight while on treatment with Remus 0.03% Ointment.
• Do not give Remus 0.03% Ointment to others even if their condition appears to be the same as yours.

Indications of Remus 0.03% Ointment

• Tacrolimus ointment is used for the short-term and discontinuous long-term treatment of patients with moderate to severe atopic dermatitis who are not adequately responsive to or intolerant of other treatments. It is also indicated for various other skin conditions such as chronic cutaneous graft-vs-host disease, hand and foot dermatitis, vitiligo, psoriasis, and more.

Pharmacology

• Tacrolimus is derived from the fungus Streptomyces tsukubaensis.
• Tacrolimus acts as a macroiide immunomodulator, primarily by inhibiting T-lymphocyte activation.
• Initially, Tacrolimus binds to an intracellular protein called FKBP-12.
• The Tacrolimus-FKBP-12 complex, along with calcium, calmodulin, and calcineurin, forms a complex.
• This complex inhibits the phosphatase activity of calcineurin, a critical enzyme in T-cell activation.
• By inhibiting calcineurin activity, Tacrolimus disrupts the entire inflammatory cascade, resulting in a decrease in inflammation.

Dosage & Administration of Remus 0.03% Ointment

• Remus 0.03% 10gm should be used 2-4 times a day on the affected area or as suggested by the doctor.
• It should be applied slowly and evenly to the skin until it is rubbed in.
• Do not use it too often or cover the treated area with a bandage or plaster.
• Treatment should continue for one week after clearing of signs and symptoms of atopic dermatitis.
• It should not be used with occlusive dressings.
• For children aged 2 years and older, Tacrolimus 0.03% ointment can be used. For children aged 16 years and older, Tacrolimus 0.1% ointment can be used.

Drug Interactions with Tacrolimus:

• Ciclosporin
• Aminoglycosides
• Amphotericin B
• Cisplatin
• NSAIDs
• Vancomycin
• Co-trimoxazole
• Acyclovir
• Ganciclovir

Contraindications

Patients having a history of hypersensitivity to Tacrolimus or any other component of the product should not use Tacrolimus ointment.

Pregnancy & Lactation

• Tacrolimus ointment is classified as Pregnancy Category C. While there have been no well-controlled studies in pregnant women, it is known to be eliminated in human milk. The decision to use Tacrolimus ointment during pregnancy or lactation should be made after considering the potential risks and benefits.

Precautions & Warnings

Avoid covering the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects. Stop using Remus 0.03% 10gm and consult your doctor if your eczema becomes infected.

Storage Conditions:

• Tacrolimus ointment should not be stored at temperatures above 30°C. It should be kept out of the reach of children and away from light.