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Ofex DS Powder For Suspension 50ml
Ofex DS is an orally administered cephalosporin antibiotic with potent bactericidal effects against a wide range of Gram-positive and Gram-negative bacteria. It is especially effective in vitro and remains stable against beta-lactamase enzymes, making it suitable for treating infections caused by resistant organisms.
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✅ Description:
Cefixime is a third-generation semisynthetic cephalosporin, active against various Gram-positive and Gram-negative bacteria. It disrupts bacterial cell wall synthesis, leading to cell death. Being highly resistant to beta-lactamases, Cefixime is effective even against organisms resistant to penicillins and some cephalosporins. The oral absorption rate is about 40–50%, unaffected by food intake.
Ofex DS is used for managing acute infections caused by susceptible pathogens, including:
- Upper Respiratory Tract Infections (URTI): Such as otitis media and other URTIs where resistance to common antibiotics is suspected or where treatment failure poses a risk.
- Lower Respiratory Tract Infections: Such as bronchitis.
- Urinary Tract Infections (UTI): Including cystitis, cystourethritis, and pyelonephritis.
Effective against pathogens like Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella spp., Haemophilus influenzae, Moraxella catarrhalis, and Enterobacter spp.
ঔষধ সেবন করুন শুধুমাত্র রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects:
Generally well tolerated. Most side effects are mild and self-limiting.
- Gastrointestinal: Diarrhea, nausea, abdominal pain, indigestion, vomiting, flatulence, and rarely, pseudomembranous colitis.
- CNS: Headache, dizziness.
- Allergic reactions: Rash, itching, urticaria, fever, joint pain.
- Blood & Biochemical: Rare reversible changes including thrombocytopenia, leukopenia, eosinophilia, and mild liver/renal test elevations.
- Others: Vaginal or genital itching.
✔️ Dosage & Administration:
Adults & Children >10 years: 200–400 mg daily as a single dose or divided into two doses.
Elderly: Standard adult dose may be given; monitor renal function in severe impairment.
Children (≥6 months): 8 mg/kg/day in one or two doses.
- 6 months–1 year: 3.75 ml/day
- 1–4 years: 5 ml/day
- 5–10 years: 10 ml/day
Typhoid (children): 5 mg/kg twice daily for 10–14 days.
Children >50 kg or >10 years: Use adult dosage.
Children <6 months: Safety not established.
Renal Impairment:
- If creatinine clearance ≥20 ml/min: standard dosing
- If clearance <20 ml/min: do not exceed 200 mg once daily.
- Dialysis patients: follow the same adjustment as those with clearance <20 ml/min.
✔️ Drug Interactions:
Like other cephalosporins, it may slightly increase prothrombin time. Caution is advised when used with anticoagulants.
✔️ Contraindications:
Known allergy to cephalosporins.
✔️ Use in Pregnancy & Lactation:
There are no adequate human studies. Use only if needed during pregnancy. It is unknown whether Cefixime passes into breast milk; use with caution in nursing mothers.
✔️ Precautions & Warnings:
- Use cautiously in patients with a history of drug allergies.
- Cephalosporins may cross-react in penicillin-sensitive individuals; severe allergic reactions (including anaphylaxis) have occurred.
- May cause overgrowth of Clostridium difficile, potentially leading to antibiotic-associated diarrhea.
✔️ Overdose Management:
No specific antidote exists. Gastric lavage may be considered. Hemodialysis and peritoneal dialysis do not effectively remove the drug. Even doses up to 2 g in healthy adults have not shown unusual adverse effects.
✔️ Storage Instructions:
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Disclaimer:
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
