Clindax-B Gel

Uses of

• Treats mild to moderate acne in adults and in adolescents (aged 12 years or older)

How does

Clindax-B Gel is a combination of Clindamycin and Benzoyl Peroxide. Clindamycin works by stopping the growth of the bacteria that cause acne. Benzoyl peroxide works by inhibiting the growth of the bacteria. It also promotes the shedding of the dead skill cells. 

Side Effects of Clindax-B Gel

• Scaly skin
• Skin irritation
• Skin rash
• Burning sensation at the application site
• Blistering and peeling of skin
• Itching of skin

Quick Suggestions:

• You have been prescribed Clindax-B Gel for the treatment of acne.
• It is recommended that you use mild soap and lukewarm water to wash with, as very hot or cold water may worsen acne. Do not wash more than you normally do.
• Apply a thin layer on the affected area. It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
• Avoid contact with your eyes, nose, or mouth. Rinse it off with water if you accidentally get the cream in these areas.
• During your treatment, your doctor may ask you to use another (non-antibiotic) skin preparation from time to time. It is important that you follow your doctor's advice, as this is to help prevent your acne from becoming resistant to treatment.
• You may have to use it for a long time before your acne starts to improve. Be patient and keep using it every day. If, however, your skin has not improved even after completing the prescribed time, consult your doctor.

Indication

Clindax-B Gel is a medication used for the treatment and control of acne. It works by not only addressing acne but also has a mild drying effect, which aids in the removal of excess oil and dirt from the skin's surface. This, in turn, helps to keep your skin pores open and reduce the likelihood of further acne breakouts.

Pharmacology

Clindamycin is a semi-synthetic derivative of lincomycin. Its mechanism of action involves blocking certain processes in sensitive organisms. Specifically, it binds reversibly to the 50S ribosomal subunits, disrupting transpeptidation and translocation events. This interference ultimately inhibits the production of bacterial proteins, which is essential for the growth and reproduction of bacteria.

Benzoyl peroxide, on the other hand, possesses strong oxidizing properties. It has a modest keratolytic (ability to break down keratin) and antibacterial effect. Benzoyl peroxide is effective against the bacterium Propionibacterium acnes, which is known to be a key contributor to the development of acne vulgaris.

Both Clindamycin and Benzoyl peroxide work together effectively to combat acne because they target different aspects of the acne-causing process. Clindamycin disrupts bacterial protein production, while Benzoyl peroxide tackles the growth of Propionibacterium acnes. This combination makes them a potent treatment option for individuals dealing with acne vulgaris.

Dosage & Administration of Clindax-B Gel

Always adhere to the prescribed instructions when using Clindax-B Gel. This medication is intended for external use exclusively. Here are the steps for proper application:

• Preparation: Begin by washing the affected area of the skin with warm water. Afterward, gently pat it dry.
• Application Frequency: Apply Clindax-B Gel to the affected areas once or twice daily, typically in the morning and evening. Ensure that your skin is clean and completely dry before application.
• Thin Layer: When applying, use a thin layer of Clindax-B Gel on the affected area. Avoid excessive use.
• Drying Time: Allow the medication to thoroughly dry on your skin before applying any makeup products or cosmetics. Do not apply cosmetics or makeup before using Clindax-B Gel.
• Cosmetics Usage: It's essential not to use cosmetics or makeup products prior to applying Clindax-B Gel. If you have any concerns about the quantity of the medication to apply, refer to the medicine's label or consult your doctor for guidance.
• Skin Dryness or Irritation: If you experience skin dryness or irritation after using Clindax-B Gel, contact your doctor for advice or potential adjustments to your treatment.
• Avoid Contact with Sensitive Areas: Make sure to avoid contact with your eyes, ears, nose, or mouth when applying Clindax-B Gel. If accidental contact occurs, rinse thoroughly with water.
• Duration of Therapy: Your doctor will determine the duration of therapy based on your specific medical condition.

Interaction

It's crucial to inform your doctor about any other medications or treatments you are using, as there can be potential drug-drug interactions with Clindax-B Gel. Here are some specific medications and products to disclose to your doctor before using Clindax-B Gel:

• Other Acne Medications: Let your doctor know if you are using or have used other acne medications, such as tretinoin, isotretinoin, or tazarotene. There could be interactions or overlapping effects when combining these treatments.
• Antibiotics: Inform your doctor if you are taking antibiotics like erythromycin or sulfacetamide, which are used to treat bacterial infections. Combining antibiotics with Clindax-B Gel may affect their effectiveness or lead to unwanted interactions.
• Dapsone: Dapsone is a medication used to treat leprosy. If you are using dapsone, your doctor should be aware, as it may interact with Clindax-B Gel.
• General Anesthetics: Some general anesthetics, like pancuronium and vecuronium, are used for relaxing skeletal muscles before surgery. If you are scheduled for surgery or have recently had surgery, inform your doctor, as Clindax-B Gel may have potential interactions with these anesthetics.
• Medicated or Abrasive Soaps and Cleansers: If you are using medicated or abrasive soaps and cleansers on your skin, it's important to discuss this with your doctor. Combining these products with Clindax-B Gel may lead to skin irritation or other adverse effects.
• Alcohol-Containing Products or Astringents: Products that contain large amounts of alcohol or astringents, such as some skin cleansers or toners, can potentially interact with Clindax-B Gel. Your doctor should be aware of their use to prevent any adverse reactions.

Contraindications

If you are allergic to Benzoyl Peroxide Clindamycin or any other ingredients of Clindax-B Gel.

Pregnancy & Lactation

Category C in pregnancy indicates that while animal studies have shown adverse effects on the fetus, there is a lack of adequate and well-controlled human studies. However, potential benefits may justify its use in pregnant women despite potential concerns.

Regarding lactation, it is not advised, and information about milk excretion is unknown.

Precautions & Warnings

• Allergies: If you have a known allergy to Clindax-B Gel or any other medicines, inform your doctor.
• Skin Conditions: Do not apply the gel to cuts, open wounds, broken skin, sunburned areas, or sensitive skin.
• Oral Ingestion: Do not swallow Clindax-B Gel. If accidentally ingested, seek medical attention from a doctor.
• Eye, Ear, Nose, and Mouth Contact: Avoid contact with the eyes, ears, nose, or mouth. If accidental contact occurs, rinse thoroughly with warm water.
• Sun Exposure: While using Clindax-B Gel, avoid excessive sun exposure, as it can make your skin more sensitive to sunlight and lead to sunburn. Wear protective clothing and use sunscreen when going outdoors to protect your skin.
• Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, inform your doctor before using Clindax-B Gel.
• Duration of Use: It is recommended not to use Clindax-B Gel continuously for more than 12 weeks. Prolonged use or excessive application does not necessarily yield quicker or better results and may increase the risk of side effects like redness, irritation, skin peeling, or discomfort.
• Gastrointestinal Conditions: If you have intestinal problems or a history of ulcerative colitis (inflammation and sores in the digestive tract) or have experienced severe diarrhea due to antibiotic use, inform your doctor before using Clindax-B Gel.

Storage Conditions

Store in a cool and dry place, away from light and children.