Aknill Gel 10gm

✔️ Uses of Aknill Gel

• Acne

✔️ How does Aknil Gel work?

Aknill Gel helps in treating acne by inhibiting the function of sebaceous glands (oil glands in skin) thus, reducing the secretion of oil (sebum) in the skin. Aknill Gel also inhibits keratinization (development of a horn-like character by the epithelial tissue), which might be a cause of acne.

✔️ Side Effects of Aknill Gel

In normal use, Aknill may cause stinging, burning, or irritation, along with erythema and peeling at the site of application. If undue irritation occurs, treatment should be temporarily interrupted and resumed once the reaction subsides. If irritation persists, treatment should be discontinued.

✔️ Quick Suggestions:

• Isotretinoin is primarily used to treat severe, disfiguring nodular acne that has not responded to other acne medications or antibiotics. It may also be prescribed for other skin conditions as determined by a doctor.
• However, it is crucial to note that isotretinoin should not be used to treat women who are capable of bearing children unless all other treatment options have been exhausted and proven ineffective. This is because isotretinoin is known to cause birth defects in humans and must not be taken during pregnancy.
• For women of childbearing age, it is essential to carefully read, understand, and adhere to the pregnancy warnings associated with isotretinoin.
• Strict contraceptive measures must be followed before, during, and after treatment with isotretinoin to prevent pregnancy and avoid the risk of birth defects.

✔️ Indication of Aknill Gel

Aknill topical gel is indicated for the treatment of mild to moderate inflammatory and non-inflammatory acne vulgaris.

✔️ Pharmacology

Isotretinoin, the active ingredient in Aknill, alters progress through the cell cycle, cell differentiation, survival, and apoptosis. These actions reduce sebum production, prevent pore blockage, and inhibit the growth of acne-causing bacteria. Isotretinoin induces apoptosis in sebocytes, decreases sebum production, and reduces the formation of comedones. It may also increase immune mechanisms and alter the chemotaxis of monocytes to reduce inflammation.

✔️ Dosage & Administration of Aknil Gel

Apply Isotretinoin 0.05% gel cautiously over the affected area once or twice daily. Patients should be advised that 6-8 weeks of treatment may be required before a therapeutic effect is observed. The safety and efficacy of Isotretinoin have not been established in children, as acne vulgaris rarely presents in this age group. No specific recommendations for use in the elderly are available.

Acute overdosage of Aknill has not been reported. Accidental ingestion could induce symptoms of hypervitaminosis A, including severe headaches, nausea, vomiting, drowsiness, irritability, and pruritus.

✔️ Interaction

Concomitant use of topical medication should be exercised cautiously during therapy with Aknill, particularly preparations containing a peeling agent or abrasive cleansers.

✔️ Contraindications

Isotretinoin 0.05% gel is contraindicated in patients with known hypersensitivity to Isotretinoin.

✔️ Pregnancy & Lactation

Isotretinoin is classified as Pregnancy Category B. Topically applied Isotretinoin's safety in human pregnancy is inadequately evidenced, but systemic administration has been associated with teratogenicity. Isotretinoin should be avoided during pregnancy and lactation.

✔️ Precautions & Warnings

Avoid contact with the mouth, eyes, mucous membranes, or abraded or eczematous skin. Application to sensitive areas like the neck should be made with caution. Exposure to sunlight should be minimized, and patients with sunburn should refrain from using Aknill due to increased sensitivity to sunlight.

✔️ Storage Conditions

Store in a cool, dry place, protected from light.