Generic Name: Silver sulphadiazine 1%
Company: Jayson Pharmaceuticals Ltd.
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Indications
Silver Sulfadiazine cream is indicated in-
The topical prophylaxis against bacterial colonization and infection in burn wounds.
The topical antibacterial management of certain contaminated or infection-prone wounds, other than burns.
Pharmacology
The component of Silver Sulfadiazine's antibacterial activity has not been completely explained. After an introduction to the medication, basic changes within the bacterial cell film happen, counting mutilation and broadening of the cell and a debilitating of the cell wall film. This is often gone with by diminished reasonability in delicate strains. The silver sulfadiazine atom dissociates and the silver moiety is bound to the bacterial cells. It is accepted that, after entering the cell divider, the silver moiety is attached to deoxyribonucleic corrosive (DNA) and anticipates bacterial cell expansion. There's roughly 100 times more DNA in mammalian cells than in bacterial cells. It is thought that the proportion of silver sulfadiazine to bacterial DNA is adequately tall to anticipate bacterial division but the comparing proportion to epithelial DNA is moo sufficient not to piece epithelial cell recovery. The sulfadiazine moiety too gives a bacteriostatic activity against delicate living beings.
Administration & Dosage
The burn wounds are cleansed, and Silver Sulfadiazine is connected over the burn wound. The burn regions ought to be secured with Silver Sulfadiazine at all times. The cream ought to be connected once to twice a day by day to a thickness of around 1/16 inches or 1.5 mm. At whatever point vital; the cream ought to be reapplied to any regions from which it has been evacuated by quiet action. In case a person's persistent necessities make dressings fundamental, they may be utilized. Reapplication ought to be guaranteed promptly after hydrotherapy. Treatment with Silver Sulfadiazine ought to proceed until palatable recuperating happens, or until the burn, location is prepared for uniting. The sedate ought to not be pulled back from the restorative regimen whereas there remains the plausibility of contamination in the event that a critical antagonistic response happens.
Interaction
Enzymatic debriding agents: Silver sulfadiazine may inactivate enzymatic debriding agents, thus the concomitant use of these compounds may be inappropriate.
Oral hypoglycemic agents and phenytoin: In patients with large area burns where serum sulfadiazine levels may approach therapeutic levels, the action of oral hypoglycemic agents and phenytoin may be potentiated and it is recommended that blood levels be monitored.
Cimetidine: In patients with large-area burns, it has been reported that co-administration of Cimetidine may increase the incidence of leukopenia.
Contraindications
It is contraindicated in patients who are hypersensitive to it or any of the other ingredients in the preparation. It should not be used on pregnant women approaching or at term, on premature infants, or on newborn infants during the first 2 months of life.
Side Effect
Several cases of transient leukopenia have been reported in patients receiving Silver Sulfadiazine therapy. Other infrequently occurring events include skin necrosis, erythema multiform, skin discoloration, burning sensation, rashes, and interstitial nephritis.
Pregnancy & Lactation
Pregnancy Category B. This drug should be used during pregnancy only if clearly justified, especially in pregnant women approaching or at term. It is not known whether Silver Sulfadiazine is excreted in human milk. A decision should be made, whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use Safety and effectiveness in pediatric patients have not been established.
Precautions & Warnings
Common: In the event that hepatic and renal capacities ended up disabled and the end of sedate diminishes, aggregation may happen and suspension of this ought to be weighed against the helpful advantage being accomplished. In considering the utilization of topical proteolytic chemicals in conjunction with it, the plausibility ought to be famous that silver might inactivate such enzymes. Laboratory Tests: Within the treatment of burn wounds including broad ranges of the body, the serum sulfa concentrations may approach grown-up helpful levels (8 mg% to 12 mg%). In this manner, in these patients, it would be prudent to screen serum sulfa concentrations. Renal work ought to be carefully observed and the pee ought to be checked for sulfa gems.
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.
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