Wikitin 25 Tablet

Omarigliptin is indicated for improving blood glucose control in adults with type 2 diabetes mellitus. It may be prescribed alone or alongside other antidiabetic medicines, together with appropriate dietary and lifestyle measures.

The recommended dose of omarigliptin is 25 mg once weekly for adults with type 2 diabetes, either as monotherapy or in combination with other antidiabetic medicines, as prescribed by a doctor.

If a dose is missed, take it as soon as you remember, following the product-specific instructions for missed doses. Then resume the regular weekly schedule. Never take two doses at the same time to compensate for a missed dose.

1. Renal Impairment: Patients with severe kidney impairment or end-stage renal disease, including those receiving haemodialysis or peritoneal dialysis, require careful medical assessment. The appropriate dose should be determined according to the approved product information and the patient's kidney function. Do not rely on the renal dosing figures above without verification, as the stated creatinine clearance criteria may be inaccurate.
2. Use in Children and Adolescents: The safety and effectiveness of omarigliptin have not been established in children and adolescents. It is not recommended for this age group unless specifically advised by a qualified specialist.

Always take this medicine according to your doctor's instructions.
Omarigliptin is administered orally as a tablet. Take it according to the prescribed weekly schedule and follow the instructions provided with your specific product.

Omarigliptin may be used with other antidiabetic medicines when prescribed. However, certain combinations require additional precautions:

1. Insulin and sulfonylureas: Combining these medicines with omarigliptin may increase the risk of hypoglycaemia (low blood sugar).
2. Medicines that may increase the risk of hypoglycaemia: Some beta-blockers, salicylates, and monoamine oxidase inhibitors may affect blood glucose control or mask warning symptoms of low blood sugar.
3. Medicines that may increase blood glucose: Adrenaline, corticosteroids such as adrenocorticotropic hormone-related treatments, and thyroid hormones may affect glycaemic control.

Interactions with metformin, glimepiride, oral contraceptives, and atorvastatin should be assessed according to the patient's complete medication regimen. Inform your doctor about all prescription medicines, over-the-counter products, and supplements you use. Blood glucose monitoring may be necessary when treatment is started or adjusted.

Omarigliptin should not be used in patients with known hypersensitivity to omarigliptin or any ingredient in the formulation.

It is not appropriate as a substitute for insulin in patients with type 1 diabetes or in emergencies involving severe ketosis, diabetic coma, or diabetic precoma. Severe infections, major surgery, and serious trauma may require insulin-based treatment and closer medical supervision.

Omarigliptin is generally tolerated by many patients, but possible adverse effects include:

1. Nasopharyngitis (inflammation of the nose and throat)
2. Hypoglycaemia, particularly when used with insulin or sulfonylureas
3. Constipation
4. Diarrhoea
5. Other gastrointestinal discomfort
6. Skin reactions and subcutaneous tissue disorders

Use omarigliptin cautiously in patients who may be more susceptible to low blood sugar, including those with:

• Pituitary dysfunction or adrenal insufficiency
• Malnutrition, prolonged fasting, or irregular food intake
• A weakened or debilitated physical condition
• Intense physical activity
• Excessive alcohol consumption

Advanced age, particularly when other risk factors are present

Patients who drive, operate machinery, or perform tasks requiring alertness should understand the symptoms of hypoglycaemia and take appropriate precautions. Regular blood glucose monitoring is important, particularly when omarigliptin is combined with other glucose-lowering medicines.

Specific information on omarigliptin overdose may be limited. If an overdose is suspected, seek prompt medical advice. Treatment is generally based on the patient's symptoms and may involve supportive care and blood glucose monitoring.

• Store below 30°C in a cool, dry place.
• Protect the medicine from light and moisture.
• Keep it out of the reach of children.
• Follow any additional storage instructions on the product packaging.