Sucomet 500mg Tablet

Uses of Sucomet 500mg Tablet

• Type 2 Diabetes Mellitus

How does Sucomet 500mg Tablet work?

Sucomet 500mg Tablet works by decreasing the production and absorption of glucose in the liver and intestine, respectively. It also improves the sensitivity of insulin by enhancing the uptake and utilization of glucose.

Side Effects of Sucomet 500mg Tablet

Common side effects include gastrointestinal issues (nausea, vomiting, diarrhea, stomach pain, and loss of appetite), taste disturbances, and a decrease in vitamin B12 absorption. Lactic acidosis is a rare but serious side effect. Other side effects may include hemolytic anemia, encephalopathy, skin reactions, and hepatic function abnormalities.

Quick Suggestions:

• Consistency in meal timing is crucial for managing blood sugar levels. Try to eat your meals and snacks at the same time each day. This helps in stabilizing blood sugar and prevents spikes or drops.
• Keep an eye on your weight, and work towards achieving or maintaining a healthy weight. Weight management is essential for overall health, especially for individuals with diabetes or those at risk of heart disease.
• Engage in regular physical activity. Exercise has numerous benefits, including improving insulin sensitivity, managing weight, and promoting heart health. Consult your healthcare provider for an exercise plan that suits your needs.
• Your doctor will guide you on how to monitor your blood sugar levels at home. Regular monitoring allows you to track changes and take appropriate actions if your levels are too high or too low.
• Your healthcare provider will recommend regular blood tests to monitor your blood sugar levels. These tests help assess how well your treatment plan is working and if any adjustments are needed.
• Drink an adequate amount of water throughout the day. Dehydration can affect blood sugar levels and overall health.
• High stress levels can impact blood sugar control. Practice stress-reduction techniques like mindfulness, meditation, or deep breathing exercises.
• Take your medications exactly as prescribed by your doctor. Skipping doses or changing the dosage with

Indication

Metformin is used for the treatment of type 2 diabetes mellitus, especially in overweight patients when diet and exercise alone are insufficient for glycemic control. It can be used alone or in combination with other oral antidiabetic drugs or insulin in adults. Metformin can also be administered to children and adolescents as young as ten years old.

Pharmacology

Metformin belongs to the biguanide class and is used to lower both baseline and postprandial plasma glucose levels in type 2 diabetic patients. It enhances insulin sensitivity, increases peripheral glucose uptake and utilization, reduces hepatic glucose production, and lowers intestinal glucose absorption. Unlike sulfonylureas, metformin does not cause hypoglycemia.

Dosage & Administration of Sucomet 500mg Tablet

Metformin comes in immediate-release and extended-release tablet forms. The dosage should be individualized based on effectiveness and tolerance, without exceeding the maximum recommended daily doses.

Adults: The usual starting dose for immediate-release metformin is 500 mg twice a day or 850 mg once a day with meals. Dosage increases can be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per day. For those requiring additional glycemic control, doses may be increased to a maximum of 2550 mg per day.

Children: The usual starting dose for immediate-release metformin in children is 500 mg twice a day with meals, with dosage increases in increments of 500 mg weekly, up to a maximum of 2000 mg per day.

Metformin extended-release tablet: Swallow whole, and do not crush, cut, or chew.

Interaction

Metformin's clearance may be affected by certain drugs, such as topiramate and zonisamide, which can raise the risk of lactic acidosis. Alcohol can amplify metformin's effect on lactate metabolism.

Contraindications

Metformin should not be used in individuals with hypersensitivity to the active ingredient or any excipient, acute metabolic acidosis, severe renal impairment (eGFR <30 mL/min), dehydration, severe infection, shock, conditions causing tissue hypoxia, hepatic insufficiency, acute alcohol intoxication, or alcoholism.

Pregnancy & Lactation

Metformin use during pregnancy may increase the risk of congenital malformations and perinatal mortality. Insulin is preferred for managing diabetes during pregnancy. Metformin is excreted in breast milk, and its safety during breastfeeding is not well-established.

Precautions & Warnings

Metformin is eliminated through the kidneys, so the risk of metformin accumulation and lactic acidosis increases as renal function declines. It may lower vitamin B12 levels and increase the risk of hypoglycemia when used with insulin or insulin secretagogues.

Storage Conditions

Store below 30°C, away from light and moisture, and out of reach of children.