Empaglif-M 12.5/500 Tablet

✔️ Empaglif M 12.5/500 contains two medicines that lower blood glucose through complementary mechanisms:

• Empagliflozin: Blocks SGLT2 in the kidneys, reducing the reabsorption of glucose and increasing glucose excretion through urine.
• Metformin: Reduces glucose production by the liver and improves the body's sensitivity to insulin, helping tissues use glucose more effectively.

Together, these actions help reduce blood glucose levels.

✔️ Pharmacology

Empaglif M 12.5/500 should not be used in patients with:

• Type 1 diabetes mellitus
• Diabetic ketoacidosis or a history of recurrent DKA
• Severe renal impairment or conditions in which metformin is contraindicated
• Metabolic acidosis, including lactic acidosis
• Known hypersensitivity to empagliflozin, metformin, or any component of the formulation

Patients with severe acute illness, significant dehydration, or certain serious hepatic or cardiac conditions may require special assessment before treatment.

✔️ Empaglif M 12.5/500 may interact with several medicines, including:

• Insulin and sulfonylureas: May increase the risk of hypoglycemia.
• Other antidiabetic medicines: Blood glucose should be monitored when treatment is combined.
• Diuretics: May increase urine output and the risk of dehydration or low blood pressure.
• ACE inhibitors and ARBs: May contribute to lower blood pressure, particularly in patients who are volume depleted.
• Corticosteroids: May increase blood glucose levels.
• Beta-blockers: May make some warning symptoms of hypoglycemia less noticeable.
• Medicines affecting kidney function or metformin clearance: May increase the risk of metformin accumulation and lactic acidosis.

✔️ Benefits of Empaglif M 12.5/500

• Helps improve blood glucose control in type 2 diabetes
• Promotes glucose elimination through urine
• Reduces excessive glucose production by the liver
• Improves insulin sensitivity
• May contribute to modest weight reduction in some patients

✔️ Seek immediate medical attention if symptoms suggest:

• Diabetic ketoacidosis (DKA)
• Lactic acidosis
• Severe dehydration or low blood pressure
• Serious urinary tract infection
• Severe genital infection
• Severe allergic reaction

✔️ Side Effects:

• Increased urination
• Increased thirst
• Dry mouth
• Nausea
• Vomiting
• Diarrhea
• Abdominal discomfort or pain
• Headache
• Dizziness
• Fatigue
• Weight loss

✔️ How to Take Empaglif M 12.5/500

Take this medicine exactly according to your doctor's prescribed dose and duration. It should generally be taken with meals to reduce the risk of stomach-related side effects associated with metformin.

Swallow the tablet whole with water. Do not chew, crush, or break the tablet unless specifically instructed by your doctor.

The dosage may be adjusted gradually according to blood glucose response and tolerability.

Adult Dose

The usual initial dose of the empagliflozin/metformin combination may be 5 mg/500 mg once daily, depending on the patient's previous treatment and clinical condition. The dose can be adjusted by the doctor as required.

The maximum recommended daily amounts are:

• Empagliflozin: 25 mg/day
• Metformin hydrochloride: 2,000 mg/day

Some formulations may be prescribed twice daily with meals. The exact regimen should be determined by the treating physician.

Child Dose

The safety and effectiveness of empagliflozin/metformin combination therapy in individuals under 18 years of age have not been established. Use in children should only be considered when specifically prescribed by a qualified healthcare professional.

Renal Dose

Kidney function should be assessed before starting treatment and monitored periodically during therapy.

Use of empagliflozin/metformin may be inappropriate or contraindicated at significantly reduced kidney function. The exact eGFR threshold depends on the formulation and prescribing information; therefore, patients with impaired renal function should use this medicine only under medical supervision.

✔️ Pregnancy & Lactation

Pregnancy: Empagliflozin is generally not recommended during pregnancy, particularly during the second and third trimesters, because of potential risks to the developing fetus. Inform your doctor if you are pregnant, planning pregnancy, or become pregnant during treatment.

Breastfeeding: Empagliflozin may pass into breast milk and could potentially affect a breastfed infant. Metformin is also present in breast milk. Your doctor will determine whether breastfeeding should be continued or an alternative treatment should be used.

✔️ What If You Forget to Take Empaglif M 12.5/500?

Take the missed dose when you remember, unless it is almost time for your next scheduled dose. If the next dose is due soon, skip the missed dose and continue with your regular schedule.

Do not take two doses together to make up for a missed dose.

✔️ Inform your doctor before using this medicine if you have:

• Kidney disease or reduced kidney function
• Liver disease
• A history of urinary tract or genital fungal infections
• Recurrent dehydration or low blood pressure
• Heart problems
• A planned surgery or procedure requiring prolonged fasting
• Heavy alcohol consumption
• A history of lactic acidosis
• Conditions that may increase the risk of diabetic ketoacidosis

Maintain adequate fluid intake unless your doctor has advised you to restrict fluids.

✔️ Storage:

• Store below 30°C.
• Protect from excessive light and moisture.
• Keep the medicine in its original packaging.
• Keep out of reach and sight of children.