Pantoprazole is indicated where suppression of acid secretion is of therapeutic benefit. Pantoprazole Is registered in the foltawing indications:
Peptic ulcer diseases (PUD)
Gastro-esophageal reflux diseases
Treatment of ulcer resistant to M2 blocker
Treatment of ulcer induced by NSAIDs
Gl bleeding from stress or acid peptic diseases
Eradication of Helicobacter pylori
Prophylaxis for acid aspiration syndrome during induction of anesthesia
Tablet: The usual recommended adult oral dose is 40 mg given once daily, preferably in the morning with or without food. The duration of therapy is ranging from 2-8 weeks.
Duodenal ulcers: Pantoprazole 40 mg tablet once daily for 2-4 weeks.
Gastric ulcer: Pantoprazole 40 mg tablet once daily for 4-8 weeks.
Reflux esophagitis: Pantoprazole 40 mg tablet once daily for 4-8 weeks.
Ulcers induced by NSAIDs: Pantoprazole 40 mg tablet once daily.
Maintenance therapy: Maintenance therapy should involve the lowest effective dose of the drug. Pantoprazole both 20 mg & 40 mg doses are safe and effective in maintaining patients with healed reflux esophagitis and PUD in remission.
Duodenal ulcer and gastric ulcer: 40 mg once daily for 7-10 days
Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7-10 days
Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours
Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, followed by 40mg every 12 h
Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.
Side effects: No potentially life-threatening effects have been reported with Pantoprazole. Symptomatic adverse effects include headache and diarrhoea are two common reported adverse effects. Peripheral edema has been occasionally reported in female patients. Other side effects may include abdominal pain, dizziness, nausea, epigastric discomfort, flatulence, skin rash, pruritus etc.