Indomet 25mg Capsule

✔️ Uses of Indomet 25mg Capsule

• Osteoarthritis
• Rheumatoid Arthritis
• Ankylosing Spondylitis
• Bursitis
• Tendinitis
• Acute Gout

✔️ How does Indomet 25mg Capsule work?

Indomet 25mg Capsule contains Indomethacin, which is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that works by inhibiting the action of the enzymes cyclooxygenase-1 and 2 (COX-1 and COX-2), which are responsible for the synthesis of prostaglandins. By blocking the production of prostaglandins, which are chemical substances responsible for pain and inflammation, Indomet 25mg Capsule reduces inflammation and provides relief from pain.

✔️ Side Effects of Indomet 25mg Capsule

• Acid or sour stomach
• Diarrhea
• Nausea and Vomiting
• Indigestion
• Fever with chills
• Skin rash
• Dizziness
• Headache
• Ringing or buzzing in the ears
• Constipation
• Unusual tiredness and weakness
• Visual disturbances

✔️ Quick Suggestions:

• You have been prescribed Indomet 25mg Capsule to relieve pain and inflammation. Acupuncture, massage, and physical therapy may also be helpful.
• Take it with food or milk to prevent an upset stomach.
• Take it as per the dose and duration prescribed by your doctor. Long-term use may lead to serious complications such as stomach bleeding and kidney problems.
• It may cause dizziness, drowsiness, or visual disturbances. Use caution while driving or doing anything that requires concentration.
• Avoid smoking and alcohol consumption.
• Inform your doctor if you have a history of heart disease or stroke.
• Your doctor may regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

✔️ Indication of Indomet 25mg Capsule

Indomet 25mg Capsule is used to treat mild to moderate pain and swelling caused by osteoarthritis (wearing away of your bone's flexible tissues), rheumatoid arthritis (pain and swelling in joints), gout (deposition of crystals between your joints), ankylosing spondylitis (fusion of small bones in your spine).

✔️ Pharmacology

Indomethacin works by inhibiting the activity of the cyclooxygenase enzymes (COX-1 and COX-2) which are involved in the production of prostaglandins, chemical substances that play a role in inflammation, pain, and fever. By blocking the synthesis of prostaglandins, indomethacin reduces inflammation, relieves pain, and reduces fever. Indomethacin also has some inhibitory effect on leukocyte function and platelet aggregation. These actions contribute to its anti-inflammatory and analgesic effects. Indomethacin is used to treat various inflammatory and rheumatic disorders such as osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis. It is also used to treat pain, fever, and inflammation associated with other conditions such as bursitis, tendinitis, and acute gouty arthritis.

✔️ Dosage & Administration of Indomet 25mg Capsule

• The immediate-release formulation of indomethacin can be given orally at a dose of 25-50 mg every 8-12 hours, not exceeding 200 mg per day. For extended-release formulation, the recommended dose is 75-150 mg per day, either in a single daily dose or divided into two doses every 12 hours, not exceeding 150 mg per day.
• For bursitis/tendinitis, the immediate-release formulation can be given at a dose of 75-150 mg per day divided every 6-8 hours. The extended-release formulation can be given at a dose of 75-150 mg per day, either in a single daily dose or divided into two doses every 12 hours.
• For acute gouty arthritis, a dose of 50 mg of immediate-release indomethacin can be given orally every 8 hours for 3-5 days, which can be reduced once the pain is under control.
• For rectal pain and inflammation associated with musculoskeletal and joint disorders, an adult can insert a 100 mg suppository at night, which can be repeated in the morning if necessary.
• In children, the dosing of indomethacin depends on their age and medical condition. Children under 2 years of age should not take indomethacin as safety and efficacy have not been established. For children aged 2-14 years, a dose of 1-2 mg/kg per day can be given orally divided every 6-12 hours, not exceeding 4 mg/kg per day or 150-200 mg per day. For children aged 14 years or above, the recommended dose is 25-50 mg of immediate-release indomethacin orally every 8-12 hours, not exceeding 200 mg per day, or 75-150 mg of extended-release indomethacin per day, either in a single daily dose or divided into two doses every 12 hours, not exceeding 150 mg per day.

✔️ Interaction

Indomet 25mg Capsule can interact with medications such as ibuprofen, naproxen, aspirin, duloxetine, metoprolol, celecoxib, and prednisone, which are used to alleviate pain, depression, high blood pressure, and arthritis. Consumption of alcohol with an Indomet 25mg Capsule should be avoided to prevent increased drowsiness, dizziness, and stomach bleeding. Patients with heart failure, fluid retention, asthma, gastrointestinal problems, high blood pressure, hyperkalemia, thrombosis, anemia, rashes, platelet aggregation inhibition, CNS problems, kidney, and liver toxicity should not be given Indomet 25mg Capsule

✔️ Contraindications

Indomethacin is contraindicated in patients with ulcers, gastritis, or active ulcerative colitis, and it should be used with caution in those with a history of these conditions. In these cases, the use of Indomethacin suppositories is advised. It is also not advised for patients who have a history of hypersensitivity.

✔️ Pregnancy & Lactation

Pregnant women who are more than 32 weeks pregnant should avoid using indomethacin due to the risk of heart issues in the infant. Women with a history of ulcers, bleeding disorders, or kidney or liver disease should also avoid using indomethacin. It is important to consult with your doctor before taking any medication during pregnancy to ensure the safety of both the mother and the baby.

✔️ Precautions & Warnings

• Indomet 25mg Capsules can increase the risk of fatal heart attack, chest pain, or stroke. Therefore, it's important to inform your doctor if you are using Indomet 25mg Capsule before undergoing heart bypass surgery or graft surgery.
• Indomet 25mg capsules should not be taken if you are allergic to them, have severe heart failure, have a history of bleeding problems, or have liver or kidney problems.
• Pregnant or breastfeeding women should not take Indomet 25mg Capsule unless prescribed by their doctor.
• Indomet 25mg Capsule can cause drowsiness and dizziness, so it's important to avoid driving or operating heavy machinery while using it.
• It should not be given to children as its safety has not been established.
• Alcohol consumption should be avoided while taking Indomet 25mg Capsule, as it can increase the risk of stomach bleeding and worsen drowsiness.
• If you experience stomach pain or notice any signs of bleeding in the intestine or stomach, such as blood in stools, stop taking Indomet 25mg Capsule and consult your doctor immediately.
• Your doctor may urge you to have tests done to monitor the functioning of your liver and kidneys, blood cell levels, and the effect on your stomach and intestine.
• If you have rheumatoid arthritis, you should have your eyes tested on a regular basis.
• It is suggested that blood pressure and cardiac function be monitored.

✔️ Storage Conditions

Store in a cool and dry place protected from light. Keep out of the reach of children.