Clopidogrel & Aspirin combination is indicated for the prevention of atherosclerotic events in patients with history of symptomatic atherosclerotic disease (ischemic stroke, myocardial infarction, peripheral arterial disease.) Antiplatelet drugs decrease platelet aggregation and may inhibit thrombus formation in the arterial circulation, while anti-coagulants have little effect. It is also used for its antiplatelet activity in the initial treatment of cardiovascular disorders such as myocardial infarction and for the prevention of cardiovascular events in a variety of conditions or procedures for patients at risk.
Dosage: The recommended dose is one tablet once daily. Orally it is only recommended for adult.
Use in hepatic impaired patients: Experience in limited in patients with severe hepatic disease, who may have bleeding diatheses. Clopidogrel should be used with caution in this population.
Side effects: Salicylates may induce hypersensitivity, asthma, urate kidney stones, chronic gastro intestinal blood loss, tinnitus, nausea and vomiting. The clinically important adverse reactions of Clopidogrel are as follows-Gastrointestinal haemorrhage, agranulocytosis dyspepsia, gastritis, constipation, diarrhoea, rash, palpitation, vomiting, paresthesia, neuralgia, gout, arthritis, clotting disorder, anemia, anxiety, insomnia, cataract, conjunctivitis, leukopenia, granulocytopenia, urticaria.