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Generic Name: Aspirin 75mg + Clopidogrel 75mg
Manufacturer/Distributor: Beximco Pharmaceuticals Ltd.
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✅ Description:
Indications of Odrel Plus Tablet
In patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation Myocardial Infarction (NSTEMI)] and acute ST-segment elevation ACS [ST-elevation Myocardial Infarction (STEMI)], it is advised to reduce the rate of Myocardial Infarction (MI) and Stroke.
Recent MI, recent Stroke, or existing Peripheral Arterial Disease: It is advised to reduce the rate of MI and Stroke in patients with established peripheral arterial disease or a history of recent Myocardial Infarction (MI) or recent Stroke.
Pharmacology of Odrel Plus Tablet
Clopidogrel is a prodrug that is used to treat blood clots. The irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets suppresses platelet activation and aggregation. At 2 hours after single oral dosages, dose-dependent suppression of platelet aggregation can be noticed. On the first day, repeated 75 mg doses decrease ADP-induced platelet aggregation, and inhibition achieves a stable state between Days 3 and 7.
Aspirin prevents platelet aggregation by inhibiting platelet cyclooxygenase irreversibly, preventing the production of thromboxane A2, a potent inducer of platelet aggregation and vasoconstriction.
Dosage & Administration of Odrel Plus Tablet
The recommended oral dose is one tablet daily.
Interaction of Odrel Plus Tablet
Oral anticoagulants, NSAIDs, Metamizole, SSRIs, CYP2C19 inhibitors increase the risk of bleeding. It shows interaction with Tonofovir, Valproic acid, Varicella vaccine, Acetazolamide and Nicorandil.
Contraindications
This combination is contraindicated in the following conditions: Hypersensitivity to the drug substance or any component of the product. Active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
Side Effects of Odrel Plus Tablet
This combination is generally well tolerated.
Pregnancy & Lactation
In pregnant women, there are no sufficient and well-controlled trials. It should only be taken if absolutely necessary throughout the first and second trimesters of pregnancy. During the third trimester of pregnancy, it is not recommended. Clopidogrel is not known to be excreted in human breast milk, however, it is known to be excreted in human milk. During breastfeeding, this drug should be avoided.
Precautions & Warnings
This combination may cause bleeding to take longer.
TTP (thrombotic thrombocytopenic purpura) has been documented seldom as a side effect of this combination.
Reye's syndrome is a condition that affects people. Individuals with chicken pox, influenza, or flu symptoms may develop Reye's syndrome. Patients receiving this combination or who have a history of hypersensitivity to other thienopyridines have suffered rash, angioedema, or hematologic reactions.
Storage Conditions
Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.
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