Daomin 500mg Tablet | Metformin | Type 2 Diabetes | ePharma
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Daomin 500mg Tablet

Generic: Metformin Hydrochloride

Type: Tablet

Pack Size: 10 Pcs

Daomin 500mg Tablet is an antidiabetic medicine that helps to control blood sugar in people with type 2 diabetes mellitus.


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Discount Price: ৳ 37.2
MRP: ৳ 40 7% Off

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✅ Description:

METFORMIN falls under the category of anti-diabetic medications called biguanides and is utilized to treat diabetes. Its primary purpose is to reduce elevated blood glucose levels in individuals with type 2 diabetes. Type 2 diabetes, a persistent condition, disrupts the body's glucose processing. Individuals with this type of diabetes either do not generate sufficient insulin or experience difficulties with insulin's effectiveness (insulin resistance). This form of diabetes is often referred to as adult-onset diabetes due to its prevalence in middle-aged and older individuals.

METFORMIN is typically prescribed for type 2 diabetes cases where diet and exercise alone are insufficient to regulate blood sugar levels. It is the initial treatment option for type 2 diabetes patients. METFORMIN functions by restoring the body's sensitivity to insulin, curbing the liver's glucose production, and retarding sugar absorption in the stomach and intestines. Moreover, METFORMIN is sometimes employed off-label for managing polycystic ovary syndrome (PCOS) in women. It aids in normalizing menstrual cycles by rebalancing hormonal levels, decreasing blood sugar levels, and fostering ovulation.

Generally, METFORMIN is associated with mild side effects. These may encompass diarrhea, nausea, vomiting, or a metallic taste in the mouth. In rare instances, it could lead to lactic acidosis, a condition marked by excessive lactic acid in the body, causing symptoms like dizziness, drowsiness, and muscle pain. Combining METFORMIN with intense exercise, excessive alcohol consumption, or skipped meals might lead to decreased blood sugar levels. It is advisable to consult a doctor if any of these circumstances arise or if urgent medical attention is required for any underlying health conditions.

The efficacy of METFORMIN is optimized when complemented by a healthy lifestyle. This involves shedding excess weight for individuals with a BMI over 25, adopting a low-calorie diet low in fats and sugars, and engaging in regular physical activity totaling at least 150 minutes per week.

Safety Advices


Alcohol
UNSAFE

Avoid consuming alcohol in combination with METFORMIN to prevent potential side effects like lactic acidosis.


Pregnancy
CONSULT YOUR DOCTOR

METFORMIN is generally not recommended during pregnancy. However, your doctor might prescribe it if they believe the benefits outweigh the risks. Do not take METFORMIN without your doctor's guidance.


Breastfeeding
CONSULT YOUR DOCTOR

It is not known whether Daomin 500mg Tablet passes into breast milk. Hence is not recommended for use during breastfeeding. Your physician may advise a safer alternative with the same therapeutic effect based on your clinical condition.


Driving
CAUTION

METFORMIN monotherapy does not induce hypoglycemia and does not affect your ability to drive or operate machinery.


Kidney
CAUTION

Exercise caution when using METFORMIN, especially if you have a history of kidney issues. Dosage adjustments may be necessary based on your kidney function. METFORMIN is not recommended for severe kidney disease. Regular kidney function tests are crucial while on METFORMIN.


Liver
CAUTION

Take Daomin 500mg Tablet cautiously, particularly if you have a history of liver conditions. Your doctor might need to adjust the dosage.

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✔️ Uses of Daomin 500mg Tablet

It is used in adults and in children (aged 10 years or older) to treat:

  • Type II diabetes mellitus
✔️ How does

Daomin 500mg Tablet decreases the absorption of glucose (sugars) from the intestine and glucose production in the liver which in turn increases the action of insulin in your body. Thereby reducing blood sugar levels.

✔️ Side Effects of Daomin 500mg Tablet

Nausea and vomiting, diarrhea, stomach discomfort, and reduced appetite are possible side effects of taking Daomin 500mg Tablet. Some individuals might also experience alterations in taste, including a metallic taste in the mouth. If any of the following severe side effects manifest, it's advised to discontinue the medication and promptly seek medical guidance from your doctor:

  • Serious Allergic Reaction: Symptoms such as hives, and swelling of the face, lips, tongue, or throat that hinder breathing or swallowing could indicate a severe allergic reaction.
  • Signs of Liver Issues: If you notice symptoms like nausea, vomiting, stomach pain, unusual or unexplained fatigue, loss of appetite, dark-colored urine, or yellowing of the skin or eyes, it might point to liver problems.
  • Signs of Lactic Acidosis: Lactic acidosis can exhibit symptoms like cold extremities (hands or feet), dizziness or lightheadedness, slow or irregular heartbeat, weakness or fatigue, unusual muscle pain, breathing difficulties, drowsiness, stomach pains, and nausea or vomiting. If you experience these symptoms, it's essential to seek medical attention promptly.
✔️ Quick Suggestions:
  • Daomin 500mg Tablet is an oral anti-diabetic medicine. It is used for the management of type 2 diabetes mellitus.
  • Before starting this medicine, inform the doctor if you are pregnant, planning a pregnancy, or breastfeeding, and about your complete medical history.
  • You can make some lifestyle changes while taking this medication to improve your health, such as giving up smoking, consuming less alcohol, exercising regularly, and adhering to a healthy, balanced diet
  • Talk to your doctor if you have conditions like heart failure, lung failure, shock, heart attack, etc.
  • Take this medicine in the exact dose and duration as recommended. Do not take more than the prescribed dose.
  • Daomin 500mg Tablets should not be used in children below 10 years of age.
✔️ Indication

Metformin, often used in the treatment of type 2 diabetes mellitus, is particularly beneficial for overweight individuals when dietary adjustments and physical activity alone are insufficient to regulate blood sugar levels.

For adults: Metformin can be administered either on its own or in conjunction with other oral antidiabetic medications or insulin. For children aged 10 and older and adolescents: Metformin can be employed as a standalone treatment or in conjunction with insulin.

Clinical studies have indicated that overweight adults with type 2 diabetes who are prescribed metformin as an initial therapy following dietary management experience a reduction in the risk of diabetic complications.

✔️ Pharmacology

Metformin is categorized as an oral antihyperglycemic medication, specifically a biguanide type, used to manage type 2 diabetes. It effectively reduces both baseline and after-meal blood glucose levels. Its mode of action differs from that of sulfonylureas and it does not lead to episodes of low blood sugar (hypoglycemia). Metformin operates by multiple mechanisms, including the reduction of glucose production by the liver, decreased absorption of glucose in the intestines, and enhancement of insulin sensitivity through increased glucose uptake and utilization in peripheral tissues.

✔️ Dosage & Administration of Daomin 500mg Tablet

Adult Dosage:

For Type 2 Diabetes Mellitus:

  • Regular Tablets: Begin with 500 mg twice or thrice daily, or 850 mg once or twice daily. The dosage can be gradually increased up to 2000 mg daily at intervals of at least 1 week. The maximum daily dose is 2550 mg.
  • Modified-Release Tablets: Begin with 500 mg once daily. The dose can be increased in 500 mg increments at intervals of at least 1 week, up to a maximum of 2000 mg once daily at night. If blood sugar control is insufficient, the dose may be split into 1000 mg twice daily. The maximum daily dose is 2000 mg.
  • Polycystic Ovary Syndrome: Start with 500 mg/day in the morning for 1 week, then increase to 500 mg twice daily for another week. Subsequently, the dose can be raised to 1.5-1.7 g/day in 2-3 divided doses.

Elderly Individuals: Begin and maintain doses cautiously.

For Individuals with Hepatic Impairment: Avoid use due to the risk of lactic acidosis.

Child Dosage:

  • For Type 2 Diabetes Mellitus in children above 10 years: Initiate with 500 mg once or twice daily or 850 mg once daily. The dose can be gradually raised to a maximum of 2000 mg daily in 2 or 3 divided doses, with intervals of at least 1 week.

Renal Impairment:

  • Assess the estimated glomerular filtration rate (eGFR) before starting metformin.
  • If eGFR is below 30 mL/min/1.73 m²: Metformin is contraindicated.
  • If eGFR is between 30-45 mL/min/1.73 m²: Starting metformin is not recommended. Monitor eGFR at least annually, especially for those at risk.
  • If eGFR drops below 45 mL/min/1.73 m² during metformin therapy, evaluate the benefits and risks.
  • If eGFR falls below 30 mL/min/1.73 m² during metformin use, discontinue the medication.

Administration Guidelines:

  • Take Daomin 500mg Tablet with meals or as advised by your doctor.
  • Swallow the tablet with a glass of water. Do not chew or crush the tablet.

Remember, the appropriate dose and treatment duration will be determined by your physician based on factors such as age, body weight, and the condition being treated. Do not discontinue Daomin 500mg Tablet without your doctor's guidance.

✔️ Interaction

Drug Interactions:

Before using Daomin 500mg Tablet, inform your doctor if you are taking any of the following medications:

  • Other diabetes medications (e.g., teneligliptin, rosiglitazone, pioglitazone, glimepiride)
  • Diuretics (used to manage edema and hypertension) such as furosemide, hydrochlorothiazide
  • Pain and inflammation medications (e.g., ibuprofen, celecoxib)
  • High blood pressure medications (e.g., atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
  • Asthma medications (e.g., salbutamol, terbutaline)
  • Corticosteroids (used for pain and inflammation) like hydrocortisone, prednisolone
  • Verapamil (used for heart issues)
  • Rifampicin (used for tuberculosis)
  • Cimetidine (used for stomach ulcers)
  • Dolutegravir (used for HIV infection)
  • Ranolazine (used for chest pain)
  • Trimethoprim (used for bacterial infections)
  • Cancer medications (e.g., vandetanib, crizotinib, olaparib)
  • Isavuconazole (used for fungal infections)

Overdosage:

If you or anyone else accidentally takes more than the prescribed Daomin 500mg Tablet, seek immediate medical advice from your doctor or visit the nearest hospital. Symptoms of an overdose may include vomiting, abdominal pain accompanied by muscle cramps, general discomfort along with severe fatigue, and breathing difficulties.

✔️ Contraindications

Do not take Daomin 500mg Tablet if:

  • You are allergic to metformin or any other components present in the tablet.
  • You have kidney failure or liver disease.
  • You are experiencing conditions like dehydration, shock, or severe infection.
  • You are dealing with an acid-base imbalance in the body or diabetes-related complications like diabetic ketoacidosis.
  • You have conditions such as heart failure, lung failure, shock, or a recent heart attack.
  • You are in an unconscious state due to extremely high or low blood sugar levels.
✔️ Pregnancy & Lactation
  • Pregnancy: Having uncontrolled diabetes during pregnancy, whether it's gestational or ongoing, is linked to an increased risk of congenital abnormalities and perinatal mortality. When a person with diabetes is planning to become pregnant or is already pregnant, it's recommended that metformin not be used for diabetes treatment. Instead, insulin should be employed to maintain blood glucose levels as close to normal as possible. This approach aims to minimize the risk of fetal deformities.
  • Breastfeeding: Metformin is found in human breast milk. No adverse effects have been observed in breastfed infants. Nevertheless, because there is limited data available, it's not recommended to breastfeed while undergoing metformin treatment. The decision to continue or discontinue breastfeeding should be carefully weighed, considering both the benefits of breastfeeding and the potential risks of any adverse effects on the child.
✔️ Precautions & Warnings
  • Certain diabetic individuals using METFORMIN may encounter a severe condition called lactic acidosis, marked by excessive lactic acid buildup in the blood.
  • Proper liver and kidney function are essential to eliminate excess lactic acid.
  • If you have kidney disease, indicated by a blood test, you should avoid taking metformin.
  • METFORMIN might lead to reduced vitamin B-12 levels, so consider undergoing annual blood tests to assess both blood sugar and vitamin levels.
  • When combined with insulin, METFORMIN can significantly decrease blood sugar levels. In such cases, a doctor may adjust the insulin dose accordingly.
✔️ Storage Conditions

Keep the temperature below 30°C and keep it away from light and moisture. Keep out of children's reach.

Frequently Asked Questions (FAQ)

The effect of Daomin 500mg Tablet can be observed within three hours of intake.

The duration for which Daomin 500mg Tablet shows its effect in your body is 8 hours.

If you forget to take METFORMIN, do NOT take a double dose to make up for your forgotten dose. Taking overdose might cause your sugar level to fall down rapidly. Try to take the next dose at the usual time.

Prior to using Daomin 500mg Tablet, let your doctor know about any liver, kidney, or heart issues you have. Also, inform your doctor if you've experienced severe systemic infections or substantial dehydration from recent excessive vomiting or diarrhea. Complement the treatment with the dietary and lifestyle adjustments recommended by your doctor for improved outcomes. If you are pregnant or breastfeeding, consult your doctor before taking Daomin 500mg Tablet.

Co-administration of Daomin 500mg Tablet with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.

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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.

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