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Proviten DX | Multivitamin [water & fat soluble] + Dextrose 5%
Proviten DX Injection | Comprehensive Multivitamin Support for Parenteral Nutrition & Critical Care
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✅ Description:
Proviten DX is indicated as a daily multivitamin supplement for adults and children aged 11 years and above who are receiving parenteral nutrition. It is also recommended when intravenous vitamin support is essential, such as in:
- Major surgeries
- Extensive burns or fractures
- Severe infections
- Comatose states
- Critical illness and trauma
These conditions often induce a metabolic stress response that increases vitamin demands and depletes nutrient stores.
🛡 Administer only under the supervision of a registered physician.
✔️ Side Effects
Common or reported reactions include:
Mild: Rash, urticaria, dizziness
Severe (rare): Anaphylactic reactions, especially with IV thiamine
Use caution in patients with known allergies to B-vitamins
✔️ Composition (Per Vial)
- Vitamin A 3,500 IU
- Vitamin D₃ 220 IU
- Vitamin E 11.2 IU
- Vitamin C (Ascorbic Acid) 125 mg
- Vitamin B₁ (Thiamine) 3.51 mg
- Vitamin B₂ (Riboflavin) 4.14 mg
- Nicotinamide 46 mg
- Pantothenic Acid 17.25 mg
- Vitamin B₆ (Pyridoxine) 4.53 mg
- Vitamin B₁₂ (Cyanocobalamin) 6 mcg
- Folic Acid 414 mcg
- Biotin 69 mcg
✔️ Pharmacology
Proviten DX contains nine water-soluble and three fat-soluble vitamins formulated in a sterile, lyophilized powder. The fat-soluble vitamins are stabilized using mixed micelles to ensure enhanced solubility. Upon reconstitution, the solution is designed for intravenous injection or infusion to restore essential micronutrients during times of high metabolic demand or nutritional deficiency.
✔️ Dosage & Administration
👨⚕️ Adults & Children (≥11 years):
1 vial per day, reconstituted with 5 mL of sterile Water for Injection, 0.9% NaCl, or 5% Glucose
Administration options:
Slow IV Injection: Over a minimum of 10 minutes
IV Infusion: Dilute further and infuse slowly as part of parenteral nutrition
🕒 Use immediately after reconstitution or within 24 hours if stored at 2–8°C
✔️ Drug Interactions
Folic acid may accelerate the metabolism of antiepileptics (e.g., phenytoin, phenobarbital)
Pyridoxine may reduce levodopa effectiveness
Ascorbic acid and riboflavin can inactivate bleomycin
Monitor for enhanced response to α1-acid glycoprotein-bound drugs (e.g., propranolol, quinidine)
✔️ Contraindications
- Known hypersensitivity to any ingredient
- Pre-existing hypervitaminosis
- Thiamine intolerance
- Severe hepatic impairment or hyperparathyroidism
✔️ Use in Pregnancy & Lactation
Pregnancy Category: Not assigned – Use only if needed
Not recommended during lactation due to a lack of safety data
✔️ Precautions & Warnings
- Risk of anaphylaxis in thiamine-sensitive individuals
- Monitor liver function if administered to jaundiced or cholestatic patients
- Monitor fat-soluble vitamin levels in renal impairment
- Allergic signs (e.g., sneezing, asthma) may precede severe reactions
✔️ Storage Instructions
Before reconstitution: Store below 25°C, protect from light, do not freeze
After reconstitution: Store at 2–8°C, use within 24 hours
Discard any unused portion
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
