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Biomega Omega-3 Fish Oil 1000mg 60 Capsules
Omega-3-acid ethyl esters reduce triglyceride production by the liver, but this mechanism is not well understood. Omega-3-acid ethyl esters inhibit acyl-CoA: 1,2-diacylglycerol acyltransferase, reducing triglyceride synthesis and increasing paroxysmal beta-oxidation, which increases fatty acid metabolism. Omega-3-acid ethyl esters also inhibit the release of fatty acids by competing for enzymes involved in the synthesis of triglycerides, increase triglyceride clearance by increasing the activity of lipoprotein lipase, and decrease production of VLDL-C.
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✅ Description:
Omega 3 is indicated as an adjunct to diet to reduce very high (>500mg/dl) triglyceride (TG) levels in adult patients and as an adjunct in secondary prevention in those who have had a myocardial infarction in the preceding 3 months. It is also indicated to help reduce the joint inflammation associated with mild arthritis, mood disorders & impulse control, and age-related macular degeneration.
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✔️ Dosage & Administration
In hypertriglyceridaemia: it can be taken as a single dose of 4 capsules (4 gm) or 2 capsules (2 gm) twice daily.
In patients with a previous myocardial infarction: It can be taken 1 capsule (1 gm ) daily with food. Patients should be placed on an appropriate lipid-lowering diet before receiving Omega-3 Acid Ethyl Esters and should continue this diet during treatment.
In joint inflammation associated with mild arthritis: The dose is 2.7 gm daily.
In mood disorders & impulse control, and age-related macular degeneration: The dose is 1 capsule (1 gm) per day. Or, as directed by the registered physician.
✔️ Interaction
O3-acid ethyl esters have been given in conjunction with warfarin without haemorrhagic complications. However, the prothrombin time must be checked when O3-acid ethyl esters are combined with warfarin or when treatment with O3-acid ethyl esters is stopped.
✔️ Contraindications:
It is contraindicated in patients who exhibit hypersensitivity to any component of this medication.
✔️ Pregnancy & Lactation
Omega-3-acid ethyl esters should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether it is excreted in human milk. Caution should be exercised when Omega-3-acid ethyl esters are administered to a lactating mother.
✔️ Safety Information:
Because of the moderate increase in bleeding time (with the high dosage, i.e., 4 capsules), patients receiving anticoagulant therapy must be monitored and the dosage of anticoagulant adjusted if necessary. Use of this medication does not eliminate the need for the surveillance usually required for patients of this type. Make allowance for the increased bleeding time in patients at high risk of haemorrhage (because of severe trauma, surgery, etc). In the absence of efficacy and safety data, use of this medication in children is not recommended. During treatment with O3-acid ethyl esters, there is a fall in thromboxane A2 production. No significant effect has been observed on the other coagulation factors. Some studies with omega-3-acids demonstrated a prolongation of bleeding time, but the bleeding time reported in these studies has not exceeded normal limits and did not produce clinically significant bleeding episodes. In some patients, a small but significant increase (within normal values) in ASAT and ALAT was reported, but no data indicate an increased risk for patients with hepatic impairment. ALAT and ASAT levels should be monitored in patients with any signs of liver damage (in particular with the high dosage, i.e. 4 capsules). O3-acid ethyl esters are not indicated in exogenous hypertriglyceridaemia (type 1 hyperchylomicronaemia). There is only limited experience in secondary endogenous hypertriglyceridaemia (especially uncontrolled diabetes). There is no experience regarding hypertriglyceridaemia in combination with fibrates.
✔️ Storage:
Store below 25°C in a dry & cool place.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
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