Apsol Oral Paste

Uses of Apsol Oral Paste

• Mouth Ulcers

How does Apsol Oral Paste work?

Apsol Oral Paste inhibits the synthesis of various mediators of inflammation (such as histamine and leukotrienes from various cells in the body) which results in decreased inflammatory activity with swelling and redness associated with minor aphthous ulcers thus treating the decrease in affected individuals.

Side Effects of Apsol Oral Paste

Temporary pain, stinging, or burning sensation at the site of application

Quick Suggestions:

• Spicy, salty, and high-sugar foods can aggravate mouth ulcers. It is recommended to avoid them during the healing process.
• Ensure you have a well-balanced diet that includes multivitamins, especially B12, folate, zinc, and iron. These nutrients can support the healing process.
• Brush your teeth after meals and floss regularly to keep your mouth clean and prevent further irritation.
• Rinsing your mouth with salt water can provide relief and promote the healing of mouth ulcers.
• Numbing the area with ice or sucking on ice chips can help alleviate pain temporarily.
• Smoking can further irritate mouth ulcers and delay the healing process. Quitting smoking is recommended.
• Apply Amlexanox as prescribed by your doctor, typically after brushing and flossing post meals and at bedtime. Avoid direct contact with the eyes, and if accidental contact occurs, wash the eyes with water.

Indication of Apsol Oral Paste

Amlexanox is indicated for the treatment of aphthous ulcers in people with normal immune systems.

Pharmacology

The exact mechanism by which Amlexanox accelerates the healing of aphthous ulcers is not fully understood. In vitro studies have shown that Amlexanox is a potent inhibitor of the formation and release of inflammatory mediators, such as histamine and leukotrienes, from various immune cells including mast cells, neutrophils, and mononuclear cells. When administered orally to animals, Amlexanox has demonstrated anti-allergic and anti-inflammatory effects and has been shown to suppress both immediate and delayed hypersensitivity reactions. However, the specific relevance of these activities of Amlexanox to its effects on aphthous ulcers has not been established. Further research is needed to fully understand the mechanism of action of Amlexanox in promoting the healing of aphthous ulcers.

Dosage & Administration of Apsol Oral Paste

1. Apply the paste as soon as possible after noticing the symptoms of an aphthous ulcer.
2. Use the paste four times daily, preferably after breakfast, lunch, dinner, and at bedtime.
3. Before applying the paste, dry the ulcer(s) by gently patting it with a soft, clean cloth.
4. Wash your hands before applying the paste.
5. Moisten the tip of your index finger and squeeze a small dab of paste (approximately ¼ inch or 0.5 cm) onto the fingertip.
6. Gently dab the paste onto each ulcer. Repeat the process if you have more than one ulcer.
7. Wash your hands after applying the paste.
8. Continue using the paste until the ulcer heals.
9. If significant healing or pain relief has not occurred within 10 days, it is important to consult your physician.

Always follow the instructions provided by your physician for the specific use of Apsol Oral Paste 5 gm. Apply a thin layer of the paste on the affected area gently. The correct dose and duration of use will be determined by your physician based on factors such as your age, body weight, and the severity of your condition.

Please note that Apsol Oral Paste 5 gm is intended for use in the oral cavity only.

Interaction

There is a potential interaction between monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs) or related antidepressants. MAOIs and SSRIs work on different neurotransmitters in the brain, and when taken together or in close proximity, they can lead to a potentially dangerous condition known as serotonin syndrome.

To prevent serotonin syndrome, it is generally recommended to allow a washout period between discontinuing an MAOI and starting an SSRI or related antidepressant. This washout period is typically two weeks for SSRIs and related antidepressants before starting an MAOI. Conversely, it is recommended to wait at least one week (or longer, depending on the specific medication) after discontinuing an SSRI or related antidepressant before starting an MAOI.

The washout period helps ensure that the previous medication has been cleared from the body and reduces the risk of serotonin syndrome. However, it's essential to follow the specific recommendations of a healthcare professional and carefully consider individual circumstances, as the timing may vary depending on the specific medications involved.

Serotonin syndrome is a potentially life-threatening condition characterized by symptoms such as agitation, confusion, rapid heartbeat, high blood pressure, dilated pupils, and tremors, and in severe cases, it can lead to seizures or loss of consciousness. If someone experiences these symptoms, they should seek immediate medical attention.

It's important to always consult with a healthcare professional or pharmacist for specific guidance and recommendations regarding medication interactions, including MAOIs and SSRIs or related antidepressants.

Contraindications

If you are allergic to Amlexanox, Lidocaine, or any other ingredients of Apsol Oral Paste.

Pregnancy & Lactation

pregnancy class B. Teratological studies on animals did not reveal any unfavorable effects on the fetus, but no adequate and well-researched studies in pregnant women exist. Thus, this medication should only be used during pregnancy if absolutely necessary.

Amlexanox was discovered in the milk of lactating rats; as a result, care should be taken when giving Amlexanox oral paste to a nursing mother.

Precautions & Warnings

• Remember to wash your hands after applying the Amlexanox oral paste to ulcers using your fingertips. If there is accidental contact with the eyes, they should be washed promptly.
• The use of Apsol Oral Paste should be avoided in patients with weak immune systems, such as those with long-term diseases like cancer or HIV, or those using immunosuppressants. However, if recommended by a physician, it can be used under their guidance.
• If you develop a rash or experience contact mucositis (inflammation of the oral mucosa due to contact with an allergen), it is advised to discontinue the use of Apsol Oral Paste 5 gm and consult your physician.
• If there is no improvement in your condition within 10 days of using Apsol Oral Paste 5 gm, it is important to inform your physician.
• Please note that Apsol Oral Paste 5 gm is not recommended for use in pregnant and breastfeeding women, as well as in children, adolescents (aged below 18 years), and elderly patients due to the lack of sufficient safety and efficacy data.

Storage Conditions

Store Apsol Oral Paste at room temperature in a cool and dry place. Keep it out of the reach of children and pets.