Revira 500mg Tablet 1 Strip

✔️ Uses of Revira Tablet

• Herpes labialis
• Genital herpes infection
• Herpes zoster

✔️ Revira is prescribed for treating infections caused by the Varicella zoster virus (VZV) and Herpes simplex virus (HSV) in various conditions:

• Herpes Zoster (Shingles) & Ophthalmic Zoster: Suitable for immunocompetent adults and those with mild to moderate immunosuppression.
• Genital Herpes (HSV) Treatment & Suppression:
  • First-time and recurrent genital herpes infections in both immunocompetent and immunocompromised adults and adolescents.
  • Long-term suppression of genital herpes in the same groups.
• Ocular HSV Infections: Treatment and prevention of recurrent episodes.
• Cytomegalovirus (CMV) Prophylaxis: Used to prevent CMV infection in adults and adolescents following solid organ transplantation.

✔️ Quick Suggestions:

• Do not skip any doses and finish the full course of treatment even if you feel better.
• Drink plenty of water while on treatment with this medicine. This helps to prevent dehydration and kidney damage.
• If you have genital herpes, use barrier methods (condoms) for contraception and avoid sexual contact while the sores are present.
• Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

✔️ Benefits of Revira Tablet

For Herpes Labialis (Cold Sores)
Revira 500mg Tablet aids in the treatment of herpes labialis, commonly known as cold sores, which typically appear as painful blisters around the lips. The first outbreak may also be accompanied by fever, sore throat, and swollen lymph nodes. This medication helps accelerate healing and reduces the chances of recurrence.

For Genital Herpes Infection
Genital herpes is a sexually transmitted infection that leads to painful sores and discomfort in the genital area. It affects both men and women and can cause itching, irritation, and pain. Revira 500mg Tablet helps alleviate these symptoms while also inhibiting the replication of the virus, preventing further spread.

For Herpes Zoster (Shingles)
Herpes zoster, commonly known as shingles, is a viral infection that leads to a painful rash. Revira 500mg Tablet helps reduce both the duration and severity of the condition, particularly when taken early after the rash appears. Supporting overall immune health and maintaining proper hygiene are essential in preventing shingles outbreaks.

✔️ For Varicella Zoster Virus (Shingles)

• Immunocompetent Adults: 1000 mg (one tablet) three times daily for 7 days.
• Immunocompromised Adults: 1000 mg three times daily for at least 7 days, continuing 2 days after lesions have crusted.
• Renal impairment, especially in patients with pre-existing kidney issues
• ncrease the risk of adverse effects; careful monitoring is recommended.

✔️ For Herpes Simplex Virus (HSV) Infections

Immunocompetent Adults & Adolescents (12+ years): 500 mg twice daily.

• Recurrent outbreaks: 3-5 days.
• Initial episodes (more severe cases): Up to 10 days.
• Best taken at the earliest signs of symptoms.

Herpes Labialis (Cold Sores):

• 2000 mg twice in one day (12-hour gap between doses).
• Treatment should be initiated at the first symptoms (tingling, itching, or burning).

Immunocompromised Adults:

• 1000 mg twice daily for at least 5 days (can extend up to 10 days for severe cases).
• Treatment should begin within 48 hours of symptom onset.

✔️ For Long-Term Suppression of Genital Herpes

• Immunocompetent Adults & Adolescents (12+ years): 500 mg once daily.
  • If outbreaks are frequent (10+ per year), 250 mg twice daily may be more effective.
  • Treatment should be reassessed after 6 to 12 months.
• Immunocompromised Adults: 500 mg twice daily with periodic re-evaluation.

✔️ For CMV Prophylaxis (After Transplantation)

• 2000 mg four times daily, starting as soon as possible post-transplant.
• Usually continued for 90 days (longer for high-risk patients).

✔️ Common side effects may include:

• Headache, nausea, dizziness
• Gastrointestinal issues (vomiting, diarrhea, abdominal pain)
• Skin reactions (rash, itching, photosensitivity)
• Neurological symptoms (confusion, hallucinations, agitation, tremors) – more common in elderly or renally impaired patients

✔️ Symptoms of overdose include:

• Acute kidney failure, confusion, hallucinations, agitation, unconsciousness, and vomiting.
• Elderly patients and those with renal impairment are more vulnerable to overdose-related complications.
• Hemodialysis can help remove excess drug in severe cases.

✔️ Drug Interactions

• Caution is advised when taken with nephrotoxic drugs, including aminoglycosides, methotrexate, ciclosporin, and tacrolimus, due to potential kidney damage.
• Cimetidine & Probenecid can increase valacyclovir levels, requiring dosage adjustments.
• Concurrent use with mycophenolate mofetil may alter drug concentrations.

Side Effects

Overdose Effects

Therapeutic Class

Storage Conditions

✔️ Contraindications

Hypersensitivity to Valacyclovir, Acyclovir, or any inactive ingredients.

✔️ Use in Pregnancy & Breastfeeding

• Pregnancy: No significant risks have been found, but should be used only when the benefits outweigh potential risks.
• Breastfeeding: A small amount of Acyclovir is excreted in breast milk, but the dose absorbed by an infant is minimal. Should be used with caution.

✔️ Precautions & Warnings

• Hydration: Ensure adequate fluid intake, especially for elderly patients, to prevent kidney complications.
• Renal Impairment & Elderly Patients: Dosage adjustments may be necessary to reduce the risk of neurological side effects.
• Liver Disease & Transplantation: Caution is advised for doses above 4000 mg/day due to limited data.
• Genital Herpes Transmission: Even with treatment, patients should avoid sexual activity during outbreaks to prevent transmission.
• CMV Prophylaxis: Higher doses may i

✔️ Storage:

Store in a cool, dry place away from children.