3RD Cef is a broad-spectrum, orally active third-generation cephalosporin antibiotic. It exerts bactericidal action against many gram-positive and gram-negative organisms and remains stable in the presence of beta-lactamase enzymes.
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Cefixime, a semisynthetic third-generation cephalosporin, inhibits bacterial cell wall synthesis, leading to cell death. It maintains strong resistance against beta-lactamase degradation, rendering it effective even against some resistant bacterial strains. Bioavailability is approximately 40–50%, regardless of food intake.
3RD Cef is prescribed for the treatment of infections caused by susceptible microorganisms, including:
It is effective against pathogens such as Streptococcus pneumoniae, S. pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella spp., Haemophilus influenzae (both beta-lactamase positive and negative), Moraxella catarrhalis, and Enterobacter spp.
Adults & Children (>10 years or >50 kg): 200–400 mg daily, as a single dose or in two divided doses.
Children (6 months–10 years):
Typhoid: 5 mg/kg twice daily for 10–14 days
Elderly: Same as adults, with renal function monitoring.
Renal Impairment:
Not recommended for children under 6 months due to a lack of safety data.
Generally well tolerated. Reported adverse effects include:
Known allergy to cephalosporins.
Cefixime may prolong prothrombin time. Monitor if the patient is on anticoagulants.
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