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Rimactane 450/300mg Tablet 1 Strip
- Rimactazid 450 is prescribed to treat TB.
- Both rifampicin and isoniazid are bactericidal agents effective against TB bacteria. Rifampicin blocks bacterial RNA polymerase, while isoniazid inhibits cell wall synthesis, targeting both extracellular and intracellular bacteria.
- Complete the full course of treatment, even if you feel better. Stopping early may lead to recurrence.
- Take the medication on an empty stomach, ideally at the same time every day.
- It may cause reddish-orange discoloration of bodily fluids like urine, sweat, and saliva—this is normal and not harmful.
- Your doctor may monitor your liver function during treatment. Contact your doctor immediately if you notice yellowing of the skin or eyes, dark urine, or stomach pain.
- Avoid alcohol while on Rimactazid 450, as it may increase the risk of liver damage.
- Use alternative contraception methods, as hormonal contraceptives may be less effective.
- Avoid taking antacids within two hours of taking Rimactazid 450.
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✅ Description:
Rimactazid 450 is a combination medication used to treat tuberculosis (TB). It inhibits the growth of the bacteria responsible for the infection. This prescription medicine must be taken as directed by a doctor, preferably on an empty stomach at a consistent time each day.
Do not exceed the recommended dose, as it may harm your body. In case of a missed dose, take it as soon as you remember. Completing the full course of treatment is essential, even if symptoms improve, as stopping the medication early may reduce its effectiveness.
While it may take time for the medication to show results, contact your doctor if your symptoms worsen or persist. Common side effects include nausea, vomiting, fever, dark-colored urine, sweating, or increased saliva production. Staying hydrated may help mitigate these effects. Seek immediate medical help for severe allergic reactions or worsening side effects.
Inform your doctor about any ongoing medications or underlying health conditions before starting Rimactazid 450. Pregnant and breastfeeding women should consult their doctor before use. Alcohol consumption should be avoided as it may cause drowsiness or interact with the drug. Your doctor may recommend laboratory tests to monitor the medication's effects during treatment.
Safety Advices
Alcohol
UNSAFE
Consuming alcohol while using Rimactazid 450 may lead to symptoms like flushing, rapid heartbeat, nausea, thirst, chest pain, and low blood pressure, also known as a Disulfiram reaction.
Pregnancy
SAFE IF PRESCRIBED
Rimactazid 450 might be unsafe during pregnancy. While limited human studies exist, animal studies indicate potential harm to the developing baby. Your doctor will carefully weigh the benefits against the risks before prescribing this medication.
Breastfeeding
SAFE IF PRESCRIBED
Rimactazid 450 is considered safe for breastfeeding. Research indicates the drug does not significantly pass into breast milk and is unlikely to harm the infant.
Driving
CAUTION
Rimactazid 450 may cause side effects that impair your ability to drive, such as seizures, mental health disturbances, and optic neuritis (inflammation of the optic nerve that can result in vision loss).
Kidney
CONSULT YOUR DOCTOR
Patients with kidney disease should use Rimactazid 450 with caution. Dose adjustments might be necessary, so consult your doctor for advice.
Liver
CONSULT YOUR DOCTOR
Rimactazid 450 should also be used cautiously in individuals with liver conditions. Dose modifications might be required, and it is not recommended for use in those with severe liver disease.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Rimactane 450/300
Treatment of Tuberculosis (TB).
✔️ Side Effects of Rimactane 450/300
- Dark-colored urine
- Skin rash
- Vomiting
- Jaundice
- Fever
- Elevated liver enzymes
- Nausea
- Peripheral neuropathy (tingling or numbness in hands and feet)
✔️ How Rimactane 450/300 Works
Rimactazid 450 combines two antibiotics, Rifampicin and Isoniazid, to treat tuberculosis (TB). Rifampicin deactivates an essential bacterial enzyme (RNA polymerase), preventing TB bacteria from producing proteins and reproducing. Isoniazid inhibits the bacteria from forming a protective covering, effectively killing them and eradicating the infection.
✔️ Direction of Rimactane 450/300
Take Rimactazid 450 as prescribed by your doctor. Swallow the tablet whole without chewing or breaking it. It should be taken on an empty stomach and avoided alongside tyramine-rich foods (e.g., cheese, smoked fish, meats, and certain beers).
✔️ Interactions
- Rifampicin may reduce the effectiveness of hormonal contraceptives and lower serum levels of anticonvulsants, antiarrhythmics, oral anticoagulants, antifungals, and several other drugs.
- Isoniazid may inhibit the metabolism of anticonvulsants, benzodiazepines, and theophylline. It may also enhance the CNS effects of drugs like cycloserine and disulfiram.
- Combining rifampicin with halothane increases the risk of hepatotoxicity.
- Concurrent use of isoniazid with saquinavir/ritonavir may lead to severe liver toxicity.
✔️ Dosage of Rimactane 450/300
For tuberculosis:
- Adults weighing <50 kg: 3 tablets of 150 mg/100 mg daily.
- Adults weighing >50 kg: 2 tablets of 300 mg/150 mg daily.
- Hepatic impairment: Maximum dose of 8 mg/kg daily.
✔️ Do not use Rimactazid 450 if you have the following:
- Hypersensitivity to rifamycins, isoniazid, or other excipients.
- A history of drug-induced hepatitis.
- Acute liver diseases.
- Peripheral neuritis.
✔️ Precautions
- Monitor for liver function, especially in individuals with alcohol dependency, chronic liver disease, or severe renal dysfunction.
- Use cautiously in patients over 35, those on chronic medications, or with a history of discontinuing isoniazid.
- Extra care is required for patients with peripheral neuropathy, pregnant women, injection drug users, and those with HIV.
✔️ Storage
Store below 30°C, away from light and moisture. Keep out of reach of children.
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