Ezex 0.05% Cream

✔️ Uses of Ezex 0.05% Cream

• Treats redness and itchiness of skin problems such as eczema, dermatitis, nappy rash, or insect bites and also reduces inflammation of the outer ear

✔️ How does Ezex 0.05% Cream work?

Ezex 0.05% Creamworks inside the skin cells to stop the release of these chemicals which reduces the swelling, redness, and itching.

✔️ Side Effects of Ezex 0.05% Cream

• Burning sensation
• Stinging sensation
• Opportunistic infections
• Hypersensitivity
• Hypothalamic-pituitary-adrenal axis suppression
• Cataract
• Skin peeling
• Dryness
• Irritation
• Itching
• Redness at the site of the application
• High blood pressure
• Allergic contact dermatitis
• Hypertrichosis (excessive hair growth)

✔️ Quick Suggestions:

• Application: Apply Ezex 0.05% Cream as a thin film to the affected areas two or three times daily, or as advised by your doctor.
• Use as directed: Do not use the cream more often or for a longer duration than recommended by your doctor.
• Airtight dressings: Do not cover the treated area with airtight dressings, such as bandages, unless specifically directed by your doctor, as it may increase the risk of side effects.
• Infection: If you suspect that the area of the skin being treated has become infected, stop using Ezex 0.05% Cream and consult your doctor.
• Dietary considerations: Include foods rich in quercetin (such as apples, cherries, broccoli, spinach, and blueberries) in your diet. Consuming probiotic-rich foods can help in developing the immune system against allergies. Limit intake of potential allergens like dairy products, soy, eggs, and nuts. Avoid excessive sugar consumption, as it may exacerbate inflammation. Include fruits, vegetables, whole grains, healthy fats, and fish in your diet.
• Stress management and sleep: Reducing stress and maintaining a good sleep cycle can be helpful for your skin condition.
• Avoid irritants: Avoid contact with harsh soaps, detergents, and rough fabrics that may irritate the skin.
• Clean and dry the affected area: Before applying Ezex 0.05% Cream, make sure to clean and dry the affected area properly.
• Avoid using on dressings, band-aids, and make-up: Do not apply Ezex 0.05% Cream on dressings, band-aids, or make-up unless specifically instructed by your doctor.
• Eye, nose, and mouth contact: If Ezex 0.05% Cream comes into contact with your eyes, nose, or mouth, rinse immediately with water.
• Compliance and follow-up: To effectively treat your condition, continue using Ezex 0.05% Cream as prescribed by your doctor. If your skin condition does not improve after two weeks of treatment, consult your doctor.

✔️ Indication

Ezex 0.05% Cream is a steroidal medicine usually applied to the skin for various skin conditions. 

It is used to reduce various skin conditions such as 

• Red bumpy scaly patches (Psoriasis),
• Severe itching associated with heat or sweating,
• Purple-colored patches with itching and swelling (Lichen planus).

✔️ Pharmacology

Clobetasone Butyrate is classified as a moderately potent topical corticosteroid. Corticosteroids like clobetasone butyrate work by reducing inflammation through various mechanisms. Some of the ways corticosteroids decrease inflammation include:

Stabilizing leukocyte lysosomal membranes: This prevents the release of destructive acid hydrolases from leukocytes, reducing tissue damage.

Inhibiting macrophage accumulation: Corticosteroids can reduce the number of macrophages (a type of immune cell) that accumulate in inflamed areas, thereby reducing inflammation.

Reducing leukocyte adhesion: Corticosteroids can decrease the adhesion of leukocytes to the capillary endothelium, which helps to limit their migration to inflammatory sites.

Decreasing capillary wall permeability: Corticosteroids can reduce the permeability of capillary walls, resulting in less fluid leakage into tissues and decreased edema formation.

Decreasing complement components: Corticosteroids can reduce the levels of complement components, which are involved in the immune response and can contribute to inflammation.

Antagonizing histamine activity and release of kinin: Corticosteroids can counteract the effects of histamine, a chemical involved in allergic reactions, and inhibit the release of kinins, which are inflammatory mediators.

Reducing fibroblast proliferation and collagen deposition: Corticosteroids can inhibit the proliferation of fibroblasts (cells involved in tissue repair) and decrease collagen deposition, which can help prevent excessive scar tissue formation.

✔️ Dosage & Administration of Ezex 0.05% Cream

To Administer the Cream:

• Wash your hands and dry them thoroughly.
• Squeeze out the correct amount of cream onto your index finger. Half a fingertip-sized amount should be enough to cover a patch of skin the same size as the palm of your hand.
• Gently rub the cream into the skin area that you are treating.
• Wash your hands again, unless you are applying the cream to your hands.

For adult dosing:

For corticosteroid-responsive dermatoses (skin conditions that respond to corticosteroids), the recommended adult dose is to use a 0.05% cream or ointment. Apply a thin layer of the cream or ointment once or twice daily to the affected areas. It is important not to use this medicine every day for more than 4 weeks at a time. If your symptoms persist or worsen, consult your healthcare professional.

Remember to follow the specific instructions provided by your doctor or pharmacist and do not exceed the recommended duration of use. If you have any questions or concerns, it is advisable to consult your healthcare provider.

✔️ Interaction

Ezex 0.05% Cream may potentially interact with certain medications and diseases. Here are the interactions you mentioned:

Drug-Drug Interactions:

• Pain killers (such as aspirin): There may be interactions between Ezex 0.05% Cream and pain killers like aspirin. It is advisable to consult with your healthcare provider regarding the concurrent use of these medications.
• Vitamins (ascorbic acid, cholecalciferol): Ezex 0.05% Cream may interact with vitamins like ascorbic acid (vitamin C) and cholecalciferol (vitamin D3). It is recommended to consult with your healthcare provider regarding the use of these medications together.
• Anticonvulsant (Pregabalin) and antidepressants (Duloxetine): Ezex 0.05% Cream may interact with anticonvulsants like pregabalin and antidepressants like duloxetine. It is important to discuss the potential interactions with your healthcare provider if you are using these medications.

Drug-Disease Interactions:

• Diabetes: Ezex 0.05% Cream may have interactions in individuals with diabetes. It is advisable to consult with your healthcare provider to assess the potential risks and benefits before using this cream.
• Diaper rash: Ezex 0.05% Cream may have interactions in individuals with diaper rash. It is important to consult with your healthcare provider regarding the appropriate treatment approach for diaper rash.
• Dehydration: Ezex 0.05% Cream may have interactions in individuals with dehydration. It is important to address the underlying dehydration and seek appropriate medical care before using this cream.
• Neuromuscular blockade: Ezex 0.05% Cream may have interactions in individuals with neuromuscular blockade. It is advisable to consult with your healthcare provider regarding the use of this cream in such cases.
• Ototoxicity: Ezex 0.05% Cream may have interactions in individuals with ototoxicity (ear toxicity). It is important to consult with your healthcare provider regarding the use of this cream if you have ear-related issues.
• Kidney dysfunction: Ezex 0.05% Cream may have interactions in individuals with kidney dysfunction. It is advisable to consult with your healthcare provider before using this cream if you have kidney-related issues.
• Hyperadrenocorticism: Ezex 0.05% Cream may have interactions in individuals with hyperadrenocorticism (high levels of cortisol). It is important to discuss the potential risks and benefits with your healthcare provider before using this cream.
• Ocular toxicities: Ezex 0.05% Cream may have interactions in individuals with ocular toxicities (eye toxicity). It is important to consult with your healthcare provider regarding the use of this cream if you have eye-related issues.

✔️ Contraindications

Pregnancy (in high doses): The use of Ezex 0.05% Cream should be avoided or used with caution during pregnancy, especially in high doses. It is important to consult with your healthcare provider before using this cream if you are pregnant or planning to become pregnant.

Presence of acute infections: Ezex 0.05% Cream should not be used on areas of the skin with acute infections. It is advisable to consult with your healthcare provider for appropriate treatment options in case of infections.

Treatment of rosacea, leg ulcers, acne vulgaris, widespread plaque psoriasis: Ezex 0.05% Cream may not be suitable for the treatment of certain conditions such as rosacea, leg ulcers, acne vulgaris, and widespread plaque psoriasis. It is important to discuss with your healthcare provider for the appropriate treatment approach for these conditions.

Child <1 year: Ezex 0.05% Cream should not be used in children younger than 1 year of age. It is recommended to consult with a healthcare provider for suitable treatment options for infants.

✔️ Pregnancy & Lactation

Pregnancy:

• Safety data on clobetasol use in pregnant women is not available.
• Published data suggest a significantly increased risk of low birth weight with the use of potent or very potent topical corticosteroids (>300 grams) during pregnancy.
• Pregnant women should be advised about the potential risk to the fetus and should use clobetasol on the smallest area of skin and for the shortest duration possible.

Animal studies:

• Animal reproduction studies have shown increased malformations, such as cleft palate and skeletal abnormalities, after subcutaneous administration of clobetasol to pregnant mice and rabbits.

Lactation:

• It is not known if clobetasol is excreted in breast milk or its effects on the breastfed infant or milk production.
• Systemically administered corticosteroids can appear in human milk and may interfere with infant growth or cause other adverse effects.
• The potential for detectable quantities of clobetasol in human milk following topical administration is unknown.
• To minimize potential exposure to the breastfed infant, clobetasol should be used on the smallest area of skin and for the shortest duration possible while breastfeeding.
• Breastfeeding women should avoid applying clobetasol directly to the nipple and areola to prevent direct infant exposure.

✔️ Precautions & Warnings

• Use the cream for the duration prescribed by your doctor. Do not discontinue its use without consulting your doctor.
• Avoid using Ezex 0.05% Cream if you have previously experienced a skin reaction or irritation to any steroid medicine.
• Unless advised by your doctor, do not wrap or cover the treated area with a bandage.
• Only apply Ezex 0.05% Cream on children's skin if it has been specifically prescribed by a doctor.
• Exercise caution when applying the medication on or near the eyelids or eyes. Repeated contact with the eyes can increase the risk of cataracts or glaucoma. Take care to avoid contact with the eyes.
• Prolonged and repeated use of Ezex 0.05% Cream can lead to skin thinning. Apply the cream carefully on broken or damaged skin, as well as on large surface areas of the skin.
• If you experience vision problems or any other unusual signs while using Ezex 0.05% Cream, inform your doctor immediately.
• Do not apply Ezex 0.05% Cream simultaneously with other creams or ointments, such as moisturizers. Wait for at least 30 minutes between applications of Clobetasol and other products.
• Do not use Ezex 0.05% Cream on open wounds, infected skin, cuts, or inflamed skin.

✔️ Storage Conditions

• Ezex 0.05% Cream should be stored at room temperature, away from sunlight and moist areas.
• Keep it away from children and pets.