Perkinil | Antiparkinsonian Medicine | 10mg/2ml Injection | Price | ePharma
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Home Medicines Parkinson's Syndrome Perkinil 10mg/2ml Injection 1pc
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Perkinil 10mg/2ml Injection 1pc

Generic: Procyclidine Hydrochloride

Type: Injection

Pack Size: 1 Pc

Procyclidine Hydrochloride is used for the Treatment of Parkinsons' disease


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Discount Price: ৳ 33.09
MRP: ৳ 35.2 6% Off

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✅ Description:

Anti-spasmodic agent: Procyclidine

  • Parkinson's Disease: An adjunctive treatment to manage motor symptoms associated with Parkinson's disease, including muscle rigidity and movement problems.
  • Extrapyramidal Symptoms: Addresses drug-induced movement disorders, which can occur as side effects from certain antipsychotic medications.

Procyclidine helps to manage Parkinson's disease and extrapyramidal symptoms by:

  • Reducing muscle stiffness and improving muscle control.
  • Adjusting levels of neurotransmitters in the brain helps improve movement and reduce symptoms associated with muscle rigidity.
  • It is recommended to take Procyclidine with food to minimize stomach upset.
  • Follow your doctor's instructions regarding dosage and duration of use. Do not stop taking Procyclidine without consulting your doctor, as sudden discontinuation could worsen symptoms.
  • Do not use Procyclidine if you are pregnant or breastfeeding unless advised by your doctor. The effects on the fetus or infant are not well-studied.
  • Procyclidine may cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you are sure you are alert.
  • Avoid alcohol while taking Procyclidine as it may enhance drowsiness and dizziness.
  • The safety and effectiveness of Procyclidine in children have not been established. It is not recommended for use in pediatric patients.
  • Always inform your doctor about all other medications you are taking and any underlying health conditions.
  • Regular check-ups may be necessary to monitor for potential side effects and assess the effectiveness of the treatment.

Safety Advices


Alcohol
UNSAFE

Avoid consumption of alcohol while taking Perkinil 10mg/2ml Injection as it may cause increased dizziness and drowsiness.


Pregnancy
CONSULT YOUR DOCTOR

Perkinil 10mg/2ml Injection belongs to pregnancy category C. Please consult your doctor before taking Perkinil 10mg/2ml Injection if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.


Breastfeeding
CONSULT YOUR DOCTOR

It is unknown whether Perkinil 10mg/2ml Injection passes into breastmilk. Consult your doctor before taking Perkinil 10mg/2ml Injection if you are breastfeeding.


Driving
UNSAFE

Perkinil 10mg/2ml Injection may cause dizziness, drowsiness, and blurred vision. Avoid driving and handling machinery if you experience these symptoms.


Kidney
CONSULT YOUR DOCTOR

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns.


Liver
CONSULT YOUR DOCTOR

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns.

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✔️ Uses of Perkinil 10mg/2ml Injection

Parkinson's disease and drug-induced abnormal movements.

✔️ How does Perkinil 10mg/2ml Injection work?

Perkinil IM/IV Injection works by decreasing the activity of excess acetylcholine in the brain.

✔️ Side Effects of Perkinil 10mg/2ml Injection

Common side effects include:

  • Dry mouth (most common)
  • Mydriasis (dilated pupils), blurred vision
  • Gastrointestinal issues (nausea, vomiting, epigastric distress, constipation)
  • Rarely, allergic reactions (e.g., rash) or muscular weakness
  • High doses may cause vertigo, confusion, or hallucinations
✔️ Quick Suggestions:
  • Procyclidine helps treat Parkinson's disease and drug-induced abnormal movements.
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake, and sugarless candy may help.
  • It may cause dry eyes. Avoid wearing contact lenses and inform your doctor if it bothers you.
  • It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • Inform your doctor if you suffer from glaucoma or if you have trouble passing urine.
  • Do not stop taking Procyclidine without talking to your doctor first as that may cause worsening of symptoms.
  • Monitoring of intraocular pressure is required while taking this medicine, as an increase in eye pressure may cause blurry vision.
  • You may be asked for regular monitoring of blood pressure,  intraocular pressure, kidney function, liver function, and cardiac function while taking this medicine.
✔️ Indication of Perkinil 10mg/2ml Injection

Perkinil (Procyclidine hydrochloride) is used as an adjunctive treatment for all forms of Parkinsonian syndrome. It is particularly effective in the symptomatic treatment of:

  • Idiopathic Parkinson's disease (paralysis agitans)
  • Postencephalitic Parkinsonism
  • Arteriosclerotic Parkinsonism

Additionally, Perkinil is utilized to control troublesome extrapyramidal symptoms such as pseudo parkinsonism, acute dystonic reactions, and akathisia induced by neuroleptic drugs (e.g., phenothiazine derivatives)

✔️ Pharmacology

Procyclidine hydrochloride, the active ingredient in Perkinil, is an antimuscarinic agent used in the treatment of Parkinson's disease. It works by correcting the relative cholinergic excess that is thought to result from dopamine deficiency in Parkinson's disease. Procyclidine is well absorbed from the gastrointestinal tract and rapidly disappears from tissues. Following intravenous administration, it begins to act within 5 to 20 minutes, with effects lasting up to 4 hours.

✔️ Dosage & Administration of Perkinil 10mg/2ml Injection

Intramuscular or Intravenous Injection:

  • Administer 5-10 mg, repeat if necessary after 20 minutes.
  • The maximum daily dose is 20 mg.

The safety and efficacy of Perkinil in pediatric patients have not been established. Its use in children should be considered only if the potential benefits outweigh the risks.

✔️ Interaction
  • The anticholinergic effects of procyclidine may be enhanced by other anticholinergic agents, such as amantadine.
  • The absorption of ketoconazole may be reduced if taken concurrently with procyclidine.
✔️ Contraindications

Procyclidine should be used with caution in:

  • Children and elderly patients
  • Individuals with diarrhea, cardiovascular disease, glaucoma, urinary retention, hepatic or renal impairment
✔️ Pregnancy & Lactation

The safety of procyclidine during pregnancy and lactation has not been established. Therefore, its use in these populations should be carefully weighed against potential risks.

✔️ Precautions & Warnings
  • Caution is advised in patients with hepatic or renal impairment, and children, the elderly, pregnant, or breastfeeding women.
  • Patients with mental disorders may experience a psychotic episode when Perkinil is used to treat extrapyramidal side effects of neuroleptic drugs.
  • Perkinil should not be withdrawn abruptly to avoid rebound Parkinsonism symptoms.
✔️ Storage:
  • Store below 25°C, protected from light and moisture.
  • Keep out of the reach of children.
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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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