Renexin XR is indicated for the treatment of chronic angina (heart-related chest pain). It is used to prevent angina attacks, not to relieve acute episodes. The medication works by improving how the heart uses energy, making it function more efficiently.
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Ranolazine exerts anti-anginal and anti-ischemic effects by inhibiting the late phase of the inward sodium current in heart muscle cells. This results in:
Notably, its effects are not dependent on lowering heart rate or blood pressure. QT interval prolongation occurs due to IKr (potassium current) inhibition, but without an increase in arrhythmic events at therapeutic doses.
Common (1–10%)
Occasional/Undefined Frequency
Initial Dose: 500 mg twice daily
Titration: May be increased to 1000 mg twice daily as needed
Administration: Take with or without food. Swallow whole—do not chew or crush.
Missed Dose: Take as soon as remembered. Skip if near next dose. Do not double dose.
Hepatic Impairment:
Mild: Dose adjustment may be necessary
Moderate to severe: Contraindicated
Renal Impairment:
CrCl 30–80 mL/min: Titrate cautiously
CrCl <30 mL/min: Contraindicated
Increased Ranolazine Levels With:
May Increase Levels Of:
Digoxin, Simvastatin, Atorvastatin
Potentially Dangerous With:
Store in a cool, dry place, away from direct light and moisture. Keep out of reach of children.
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