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Renexin XR 500mg Tablet 1 Strip
Renexin XR is indicated for the treatment of chronic angina (heart-related chest pain). It is used to prevent angina attacks, not to relieve acute episodes. The medication works by improving how the heart uses energy, making it function more efficiently.
- Take consistently at the same time each day
- Helps improve HbA1c and blood sugar in diabetic patients
- May cause drowsiness or dizziness—avoid driving until the effects are known
- Regular ECG monitoring is recommended, especially during dose initiation
- Maintain a heart-healthy lifestyle: quit smoking, reduce alcohol, manage stress
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✅ Description:
Ranolazine exerts anti-anginal and anti-ischemic effects by inhibiting the late phase of the inward sodium current in heart muscle cells. This results in:
- Decreased intracellular sodium and calcium overload
- Improved myocardial relaxation
- Restoration of ventricular pump function
- Reduced myocardial oxygen consumption
Notably, its effects are not dependent on lowering heart rate or blood pressure. QT interval prolongation occurs due to IKr (potassium current) inhibition, but without an increase in arrhythmic events at therapeutic doses.
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✔️ Side Effects
Common (1–10%)
- Dizziness
- Headache
- Nausea
- Vomiting
- Constipation
- Weakness
Occasional/Undefined Frequency
- Syncope, bradycardia, palpitations
- QT prolongation, visual disturbances
- Dry mouth, dyspepsia, anorexia
- Dyspnea, tinnitus, vertigo, edema
- Confusion, hematuria, hyperhidrosis
✔️
Dosage & Administration
Initial Dose: 500 mg twice daily
Titration: May be increased to 1000 mg twice daily as needed
Administration: Take with or without food. Swallow whole—do not chew or crush.
Missed Dose: Take as soon as remembered. Skip if near next dose. Do not double dose.
⚠️ Dosage Adjustments
Hepatic Impairment:
Mild: Dose adjustment may be necessary
Moderate to severe: Contraindicated
Renal Impairment:
CrCl 30–80 mL/min: Titrate cautiously
CrCl <30 mL/min: Contraindicated
✔️ Contraindications
- Significant liver dysfunction
- Concomitant use with strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, ritonavir)
- Use with CYP3A4 inducers (e.g. rifampicin, phenobarbital)
✔️ Drug Interactions
Increased Ranolazine Levels With:
- Moderate CYP3A4 inhibitors (diltiazem, fluconazole)
- P-gp inhibitors (verapamil, cyclosporine)
- CYP2D6 inhibitors (paroxetine)
May Increase Levels Of:
Digoxin, Simvastatin, Atorvastatin
- Other CYP3A4 substrates (e.g. tacrolimus, sirolimus)
- Metformin
Potentially Dangerous With:
- QT-prolonging agents (e.g. dofetilide, quinidine, sotalol)
- CYP3A4 inducers (rifampicin, phenytoin)
✔️ Precautions
- History of cardiac arrhythmias (QT prolongation, bradycardia)
- Electrolyte imbalances (low potassium or magnesium)
- Severe renal impairment
- Use with caution in patients on QT-prolonging drugs
- Not recommended during pregnancy and breastfeeding
✔️ Storage:
Store in a cool, dry place, away from direct light and moisture. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
