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Tablet Manufacturer/Distributor: Square Pharmaceuticals Ltd. Generic Name: Ranolazine 500mg Tablet
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✅ Description:
Indications
The drug ranolazine is used to treat chronic angina. Beta-blockers, nitrates, calcium channel blockers, antiplatelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers may all be combined with ranolazine. On maximal doses of amlodipine, it has been shown to reduce angina episodes in patients with coronary artery disease.
Pharmacology
Ranolazine has anti-ischemic and anti-langinal effects that are independent of heart rate or blood pressure reductions. Ranolazine's exact mechanism of action is unknown. At therapeutic doses, ranolazine can block the cardiac late sodium current (INa). The link between this inhibition and angina symptoms, however, is unknown.
Administration & Dosage
Ranolazine has anti-ischemic and anti-langinal effects that are unaffected by changes in heart rate or blood pressure. The exact mechanism of action of ranolazine is unknown. Ranolazine can block the cardiac late sodium current at therapeutic doses (INa). However, there is no known link between this inhibition and angina symptoms.
Interaction
Strong CYP 3A inhibitors: Do not take Ranolazine if you are taking a strong CYP 3A inhibitor. Limit the maximum dose of ranolazine to 500 mg twice daily when taking moderate CYP 3A inhibitors (e.g., diltiazem, verapamil, erythromycin).
Contraindications
Ranolazine is not recommended for patients who have a history of QT prolongation.
Hepatic impairment is a condition in which the liver is damaged.
Taking drugs that lengthen the QT interval
CYP3A inhibitors, such as ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir, and saquinavir, as well as diltiazem, are used.
Side Effect
Cardiac problems include bradycardia and palpitations.
Tinnitus, vertigo, and other ear and labyrinth disorders
Abdominal pain, dry mouth, and vomiting are all symptoms of gastrointestinal disorders.
Peripheral edema is one of the most common side effects at the administrative site.
Dyspnea is a symptom of respiratory, thoracic, and mediastinal disorders.
Pregnancy & Lactation
Pregnancy Category C. There are no satisfactory ponders evaluating the impact of ranolazine on the creating baby. There are no satisfactory well-controlled thinks about in pregnant ladies. Ranolazine ought to be utilized amid pregnancy as it were when the potential advantage to the persistent legitimizes the potential hazard to the fetus.lt isn't known whether ranolazine is excreted in human drain. Since of the possibility for genuine antagonistic responses from ranolazine in nursing newborn children, a choice ought to be made whether to cease nursing or to discontinue Ranolazine, taking under consideration the significance of the medicate to the mother.
Precautions & Warnings
Because co-administration of ranolazine with digoxin increases digoxin plasma concentrations by about 1.5-fold, the digoxin dose may need to be reduced as a result. When ranolazine is co-administered, the dose of other P-gp substrates may need to be reduced as well. When taking ranolazine with P-gp inhibitors like ritonavir or cyclosporine, it's best to be cautious.
Storage Conditions
Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.
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